CoMPLEX, University College London, London, UK.
Medical Physics and Bioengineering, University College London, London, UK.
Adv Exp Med Biol. 2013;789:331-337. doi: 10.1007/978-1-4614-7411-1_44.
We describe the extension of a computational model of blood flow and metabolism in the piglet brain to investigate changes in neonatal intracellular brain pH during hypoxia-ischemia (HI). The model is able to simulate near-infrared spectroscopy (NIRS) and magnetic resonance spectroscopy (MRS) measurements obtained from HI experiments conducted in piglets. We adopt a method of using (31)P-MRS data to estimate of intracellular pH and compare measured pH and oxygenation with their modelled counterparts. We show that both NIRS and MRS measurements are predicted well in the new version of the model.
我们描述了一种猪脑血液流动和代谢的计算模型的扩展，以研究缺氧缺血（HI）期间新生儿细胞内脑 pH 值的变化。该模型能够模拟从仔猪 HI 实验中获得的近红外光谱（NIRS）和磁共振光谱（MRS）测量。我们采用一种使用（31）P-MRS 数据来估计细胞内 pH 值的方法，并将测量的 pH 值和氧合与模型的对应值进行比较。我们表明，新版本的模型能够很好地预测 NIRS 和 MRS 测量结果。
