手性和区域选择性的有机金属试剂与线性多共轭硝基烯烃的共轭加成。
Enantio- and regioselective conjugate addition of organometallic reagents to linear polyconjugated nitroolefins.
机构信息
Department of Organic Chemistry, Université de Genève, 30, Quai Ernest Ansermet, 1211 Genève-4, Switzerland.
出版信息
Chemistry. 2013 Aug 19;19(34):11352-63. doi: 10.1002/chem.201300538. Epub 2013 Jul 12.
PMID:23852566
Abstract
The copper-catalysed conjugate addition of trialkylaluminium and dialkylzinc reagents to polyconjugated nitroolefins (nitrodiene and nitroenyne derivatives) is reported. A reversed Josiphos ligand L7 allows for the selective 1,4- or 1,6-addition with high enantioselectivities.
摘要
本文报道了三烷基铝和二烷基锌试剂与多共轭硝基烯烃（硝基二烯和硝烯炔衍生物）的铜催化共轭加成反应。使用反向手性 Josiphos 配体 L7 可以高对映选择性地进行 1,4-或 1,6-加成。
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