Department of Microbiology and Parasitology, Fluminense Federal University, RJ, Brazil.
J Med Virol. 2013 Nov;85(11):2016-9. doi: 10.1002/jmv.23687. Epub 2013 Jul 12.
Merkel cell carcinoma (MCC) is a rare but aggressive neuroendocrine cancer, with approximately 80% of cases associated with Merkel cell polyomavirus (MCPyV). The lack of information concerning its occurrence in non-MCC immunosuppressed populations led to the investigation of MCPyV DNA in saliva and oral biopsies from 60 kidney allograft recipients and 75 non-transplanted individuals (control group). In contrast to herpesviruses, which was also investigated (CMV, HHV-6A, and B, HHV-7) MCPyV was detected predominantly in patients with oral lesions (gingivitis and/or periodontitis) of both transplanted and non-transplanted groups (P=0.016) and in the saliva of the transplanted group (P=0.009). MCPyV co-detection with CMV (P=0.048), and HHV-6 (P=0.020) in the saliva of transplanted patients requires further investigation on a possible role of co-infection.
默克尔细胞癌（Merkel cell carcinoma，MCC）是一种罕见但具有侵袭性的神经内分泌癌，约 80%的病例与 Merkel 细胞多瘤病毒（Merkel cell polyomavirus，MCPyV）有关。由于缺乏关于其在非 MCC 免疫抑制人群中发生的信息，因此研究人员检测了 60 名肾移植受者和 75 名未移植个体（对照组）的唾液和口腔活检中的 MCPyV DNA。与疱疹病毒（也进行了研究，包括 CMV、HHV-6A、B 和 HHV-7）不同，MCPyV 主要在移植组和非移植组均有口腔病变（牙龈炎和/或牙周炎）患者的口腔（P=0.016）和移植组的唾液中检测到（P=0.009）。在移植患者的唾液中同时检测到 MCPyV 与 CMV（P=0.048）和 HHV-6（P=0.020），需要进一步研究可能的合并感染作用。
