Inoue Motoki, Sasaki Makoto, Katada Yasuyuki, Taguchi Tetsushi
Biomaterials Unit, Nano-Life Field, International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS), Tsukuba, Ibaraki, Japan.
J Biomed Mater Res B Appl Biomater. 2014 Jan;102(1):68-72. doi: 10.1002/jbm.b.32982. Epub 2013 Jul 13.
Coronary stents must not provoke an inflammatory response; however, some kinds of ions that are released from biometals induce biological reaction. In the present study, we quantitatively evaluated biological reaction of nickel-free high-nitrogen stainless steel (HNS) by endothelial cell culture, and a bioimaging system using NF-κB/luciferase transgenic mice to confirm the potential of HNS for the application of coronary stent. Endothelialization was greater with HNS than with commercial stainless steel (SUS316L). In vivo inflammatory response of HNS was lower than that of SUS316L. These differences may be related to the amounts of nickel ion eluted from the stents, as HNS did not elute nickel ion. These data suggest that HNS may be useful as a material for coronary artery stents.
冠状动脉支架不能引发炎症反应；然而，从生物金属中释放出的某些离子会诱发生物反应。在本研究中，我们通过内皮细胞培养对无镍高氮不锈钢（HNS）的生物反应进行了定量评估，并使用NF-κB/荧光素酶转基因小鼠的生物成像系统来确认HNS在冠状动脉支架应用方面的潜力。HNS的内皮化程度高于商用不锈钢（SUS316L）。HNS的体内炎症反应低于SUS316L。这些差异可能与从支架上洗脱的镍离子量有关，因为HNS不会洗脱镍离子。这些数据表明，HNS可能作为冠状动脉支架的一种材料很有用。
