Shibata S, Ochi A, Mori K
Department of Neurosurgery, Nagasaki University School of Medicine.
No Shinkei Geka. 1990 May;18(5):431-8.
The ultrastructure of the tumor vessels of primary cerebellar, subarachnoidal disseminated and extraneural metastatic medulloblastomas was studied. They were compared with those in glial, nonglial and metastatic brain tumors which have been previously reported. Twelve surgical specimens were examined. Seven tumors were limited to the vermis, the floor of the fourth ventricle and the cerebellar hemispheres. Four gross nodule seedings were demonstrated in the cerebral and spinal subarachnoid space. One metastasis was demonstrated in the subclavicular lymph node. Ultrathin section of those tumors and replica specimens were studied under the transmission electron microscope. The tumor vessels of primary medulloblastoma and glial tumors had nonfenestrated capillaries and were morphologically similar to normal brain capillaries. On the other hand, the tumor vessels of disseminated and metastatic medulloblastoma, nonglial tumors, and metastatic brain tumors had fenestrated capillaries. These findings were anticipated because the arachnoid membrane and lymph nodes have fenestrated capillaries. The presence of fenestration suggests that the tumor vessels of disseminated and metastatic brain tumors resemble the blood vessels found in normal arachnoid membrane and lymph nodes.
对原发性小脑、蛛网膜下腔播散性和神经外转移性髓母细胞瘤的肿瘤血管超微结构进行了研究。将它们与先前报道的胶质、非胶质和转移性脑肿瘤的肿瘤血管进行了比较。检查了12个手术标本。7个肿瘤局限于蚓部、第四脑室底部和小脑半球。在脑和脊髓蛛网膜下腔发现4个肉眼可见的结节播散灶。在锁骨下淋巴结发现1处转移灶。对这些肿瘤的超薄切片和复型标本进行了透射电子显微镜观察。原发性髓母细胞瘤和胶质肿瘤的肿瘤血管具有无窗孔毛细血管，在形态上与正常脑毛细血管相似。另一方面，播散性和转移性髓母细胞瘤、非胶质肿瘤以及转移性脑肿瘤的肿瘤血管具有窗孔毛细血管。这些发现是可以预期的，因为蛛网膜和淋巴结具有窗孔毛细血管。窗孔的存在表明，播散性和转移性脑肿瘤的肿瘤血管类似于正常蛛网膜和淋巴结中的血管。
