Yin Ming, Borton David A, Aceros Juan, Patterson William R, Nurmikko Arto V
School of Engineering, Brown University, Providence, RI 02912, USA.
IEEE Trans Biomed Circuits Syst. 2013 Apr;7(2):115-28. doi: 10.1109/TBCAS.2013.2255874.
A 100-channel fully implantable wireless broadband neural recording system was developed. It features 100 parallel broadband (0.1 Hz-7.8 kHz) neural recording channels, a medical grade 200 mAh Li-ion battery recharged inductively at 150 kHz , and data telemetry using 3.2 GHz to 3.8 GHz FSK modulated wireless link for 48 Mbps Manchester encoded data. All active electronics are hermetically sealed in a titanium enclosure with a sapphire window for electromagnetic transparency. A custom, high-density configuration of 100 individual hermetic feedthrough pins enable connection to an intracortical neural recording microelectrode array. A 100 MHz bandwidth custom receiver was built to remotely receive the FSK signal and achieved -77.7 dBm sensitivity with 10(-8) BER at 48 Mbps data rate. ESD testing on all the electronic inputs and outputs has proven that the implantable device satisfies the HBM Class-1B ESD Standard. In addition, the evaluation of the worst-case charge density delivered to the tissue from each I/O pin verifies the patient safety of the device in the event of failure. Finally, the functionality and reliability of the complete device has been tested on-bench and further validated chronically in ongoing freely moving swine and monkey animal trials for more than one year to date.
研发出了一种100通道的完全可植入式无线宽带神经记录系统。它具有100个并行的宽带（0.1赫兹至7.8千赫兹）神经记录通道、一个医疗级200毫安锂离子电池，该电池通过150千赫兹的感应方式充电，以及使用3.2吉赫兹至3.8吉赫兹频移键控调制无线链路进行48兆比特每秒曼彻斯特编码数据传输的数据遥测。所有有源电子器件都气密密封在一个带有蓝宝石窗口以实现电磁透明的钛制外壳中。100个单独的气密馈通引脚的定制高密度配置使得能够连接到皮层内神经记录微电极阵列。构建了一个100兆赫兹带宽的定制接收器来远程接收频移键控信号，并且在48兆比特每秒的数据速率下实现了-77.7分贝毫瓦的灵敏度以及10的-8次方误码率。对所有电子输入和输出进行的静电放电测试已证明该可植入设备符合HBM 1B类静电放电标准。此外，对从每个输入/输出引脚传递到组织的最坏情况电荷密度的评估验证了该设备在发生故障时对患者的安全性。最后，整个设备的功能和可靠性已经在实验台上进行了测试，并在正在进行的自由活动猪和猴动物试验中进行了超过一年的长期进一步验证。
