IEEE Trans Biomed Circuits Syst. 2010 Jun;4(3):149-61. doi: 10.1109/TBCAS.2010.2041350.
We present a fully differential 128-channel integrated neural interface. It consists of an array of 8 X 16 low-power low-noise signal-recording and generation circuits for electrical neural activity monitoring and stimulation, respectively. The recording channel has two stages of signal amplification and conditioning with and a fully differential 8-b column-parallel successive approximation (SAR) analog-to-digital converter (ADC). The total measured power consumption of each recording channel, including the SAR ADC, is 15.5 ¿W. The measured input-referred noise is 6.08 ¿ Vrms over a 5-kHz bandwidth, resulting in a noise efficiency factor of 5.6. The stimulation channel performs monophasic or biphasic voltage-mode stimulation, with a maximum stimulation current of 5 mA and a quiescent power dissipation of 51.5 ¿W. The design is implemented in 0.35-¿m complementary metal-oxide semiconductor technology with the channel pitch of 200 ¿m for a total die size of 3.4 mm × 2.5 mm and a total power consumption of 9.33 mW. The neural interface was validated in in vitro recording of a low-Mg(2+)/high-K(+) epileptic seizure model in an intact hippocampus of a mouse.
我们提出了一种全差分 128 通道集成神经接口。它由一个 8X16 的低功率低噪声信号记录和生成电路阵列组成，分别用于电神经活动监测和刺激。记录通道具有两级信号放大和调理，以及全差分 8 位列并行逐次逼近（SAR）模数转换器（ADC）。每个记录通道的总测量功耗，包括 SAR ADC，为 15.5μW。在 5 kHz 的带宽下，测量到的输入参考噪声为 6.08μVrms，噪声效率因子为 5.6。刺激通道执行单相或双相电压模式刺激，最大刺激电流为 5 mA，静态功耗为 51.5μW。该设计采用 0.35-µm 互补金属氧化物半导体技术实现，通道间距为 200µm，总芯片尺寸为 3.4mm×2.5mm，总功耗为 9.33mW。该神经接口在体外验证了在完整的小鼠海马体中进行的低镁（2+）/高钾（K+）癫痫发作模型的记录。
