IEEE Trans Biomed Circuits Syst. 2010 Dec;4(6):469-76. doi: 10.1109/TBCAS.2010.2081988.
Here, we demonstrate the use of a micro light emitting diode (LED) array as a powerful tool for complex spatiotemporal control of photosensitized neurons. The array can generate arbitrary, 2-D, excitation patterns with millisecond and micrometer resolution. In particular, we describe an active matrix control address system to allow simultaneous control of 256 individual micro LEDs. We present the system optically integrated into a microscope environment and patch clamp electrophysiology. The results show that the emitters have sufficient radiance at the required wavelength to stimulate neurons expressing channelrhodopsin-2 (ChR2).
在这里，我们展示了一种微发光二极管（LED）阵列的应用，该阵列可作为一种强大的工具，用于对光敏神经元进行复杂的时空控制。该阵列可以生成具有毫秒和微米分辨率的任意二维激发模式。具体来说，我们描述了一种有源矩阵控制寻址系统，可实现对 256 个单独微 LED 的同时控制。我们将系统光学集成到显微镜环境和膜片钳电生理学中。结果表明，发射器在所需波长下具有足够的辐射亮度，足以刺激表达通道视紫红质-2（ChR2）的神经元。
