Bahar Adeleh, Hosseini Esfahani Firoozeh, Asghari Jafarabadi Mohammad, Mehrabi Yadollah, Azizi Fereidoun
Diabetes Research Centre, Mazandaran University of Medical Sciences, Sari, IR Iran.
Int J Endocrinol Metab. 2013 Winter;11(1):16-22. doi: 10.5812/ijem.4477. Epub 2012 Dec 21.
The choice of what parameters are needed for the diagnosis of Metabolic syndrome (MetS) has been criticized due to the lack of an actual "gold standard" diagnostic test even in adults. This problem seems to be greater in children and adolescents.
Stability assessment of factor structure underlying metabolic syndrome (MetS) components from childhood to adolescence in a panel study.
A total number of 643 (305 boys and 338 girls) children (from 1999 to 2001), aged 6-10 years, with a complete median follow-up of 6.7 years (from 2006 to 2008) were selected among participants of Tehran Lipid and Glucose Study. We proposed 6 measured variables based on risk factors defined in Adult Treatment Panel III guidelines to describe clustering of MetS components.
The Goodness of fit of the two-factor model, extracted from exploratory factor analysis, was appropriate for boys and girls in both stages of the study using confirmatory factor analysis. Systolic blood pressure (SBP) and triglycerides (TGs), with parameter estimates (PE) of 1 and 0.75, respectively, were the greatest risk factors at baseline in boys and girls. Waist circumference with PE of 0.88 and 0.62, and SBP with PE of 0.99 and 0.86 in adolescent boys and girls, respectively, were important risk factors.
Our panel study supports the stability of the two-factor six-variable model across two developmental stages from childhood to adolescence, among which adiposity, SBP, and TG were the predominant risk factors.
由于缺乏真正的“金标准”诊断测试，即使在成年人中，代谢综合征（MetS）诊断所需参数的选择也受到了批评。这个问题在儿童和青少年中似乎更为严重。
在一项队列研究中评估从儿童期到青春期代谢综合征（MetS）各成分潜在因素结构的稳定性。
从德黑兰血脂与血糖研究的参与者中选取了643名（305名男孩和338名女孩）6至10岁的儿童（1999年至2001年），其完整的中位随访时间为6.7年（2006年至2008年）。我们基于成人治疗小组III指南中定义的风险因素提出了6个测量变量，以描述MetS各成分的聚集情况。
从探索性因素分析中提取的双因素模型的拟合优度，在研究的两个阶段使用验证性因素分析时，对男孩和女孩都适用。收缩压（SBP）和甘油三酯（TGs），参数估计值（PE）分别为1和0.75，是男孩和女孩基线时最大的风险因素。青春期男孩和女孩的腰围参数估计值分别为0.88和0.62，SBP参数估计值分别为0.99和0.86，是重要的风险因素。
我们的队列研究支持从儿童期到青春期这两个发育阶段双因素六变量模型的稳定性，其中肥胖、SBP和TG是主要的风险因素。
