Department of Cardiology and Neurology of Korean Medicine, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Evid Based Complement Alternat Med. 2013;2013:804696. doi: 10.1155/2013/804696. Epub 2013 Jun 18.
The objective of this study was to differentiate between pain-related and pain-unrelated neural responses of acupuncture at BL60 to investigate the specific effects of acupuncture. A total of 19 healthy volunteers were evaluated. fMRI was performed with sham or verum acupuncture stimulation at the left BL60 before and after local anesthesia. To investigate the relative BOLD signal effect for each session, a one-sample t-test was performed for individual contrast maps, and a paired t-test to investigate the differences between the pre- and post-anesthetic signal effects. Regarding verum acupuncture, areas that were more activated before local anesthesia included the superior, middle, and medial frontal gyri, inferior parietal lobule, superior temporal gyrus, thalamus, middle temporal gyrus, cingulate gyrus, culmen, and cerebellar tonsil. The postcentral gyrus was more deactivated before local anesthesia. After local anesthesia, the middle occipital gyrus, inferior temporal gyrus, postcentral gyrus, precuneus, superior parietal lobule, and declive were deactivated. Pre-anesthetic verum acupuncture at BL60 activated areas of vision and pain transmission. Post-anesthetic verum acupuncture deactivated brain areas of visual function, which is considered to be a pain-unrelated acupuncture response. It indicates that specific effects of acupoint BL60 are to control vision sense as used in the clinical setting.
本研究旨在区分针刺 BL60 穴时与疼痛相关和不相关的神经反应，以探究针刺的特定效应。共纳入 19 名健康志愿者进行评估。在局部麻醉前后，对左侧 BL60 穴进行假针刺或真针刺刺激，并进行 fMRI 检查。为了研究每个时段的相对 BOLD 信号效应，对个体对比图进行单样本 t 检验，对麻醉前后的信号效应差异进行配对 t 检验。与真针刺相比，局部麻醉前更活跃的区域包括额上、中、内回，顶下小叶，颞上回，丘脑，颞中回，扣带回，鸡冠和小脑扁桃体。中央后回在局部麻醉前更失活。局部麻醉后，枕中回、颞下回、中央后回、楔前叶、顶叶上回和小脑蚓部失活。BL60 穴真针刺的预麻醉期激活了视觉和疼痛传递的区域。麻醉后的真针刺则使视觉功能脑区失活，这被认为是与疼痛无关的针刺反应。这表明 BL60 穴的特定效应是控制临床应用中的视觉感知。
