IL28B基因多态性可预测丙型肝炎病毒4型慢性感染患者对标准治疗的病毒学反应。
IL28B polymorphisms predict the virological response to standard therapy in patients with chronic hepatitis C virus genotype 4 infection.
作者信息
Abdo Ayman A, Al-Ahdal Mohammed N, Khalid Saira S, Helmy Ahmed, Sanai Faisal M, Alswat Khalid, Al-Hamoudi Waleed, Ali Safiyya M, Al-Ashgar Hamad I, Al-Mdani Abdallah, Albenmousa Ali, Al Faleh Faleh Z, Al-Anazi Mashael, Khalaf Nisreen, Al-Qahtani Ahmed
机构信息
Division of Gastroenterology, Department of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia ; Liver Disease Research Centre, King Saud University, Riyadh, Kingdom of Saudi Arabia.
出版信息
Hepatol Int. 2013 Feb 8;7(2):533-8. doi: 10.1007/s12072-013-9421-8. Print 2013 Jun.
BACKGROUND
Genome-wide association studies have recently revealed that several single-nucleotide polymorphisms (SNPs) in the interleukin (IL) 28B genes can predict the sustained virological response (SVR) to pegylated interferon-α2a/b plus ribavirin in hepatitis C virus (HCV)-genotype 1 patients. However, data for patients infected with HCV genotype 4 (HCV-G4) are limited.
AIM
We analyzed the association of IL28B SNPs (hematological, biochemical, virological, and pathological factors) with SVR in the HCV-G4 monoinfected cohort of patients.
PATIENTS AND METHODS
One hundred twenty-nine treatment-naïve HCV-G4 patients undergoing treatment were recruited from three tertiary care centers in Saudi Arabia. Five IL28B SNPs (rs12979860, rs12980275, rs8105790, rs8099917, and rs72486680) were identified by polymerase chain reaction and DNA sequencing. SVR was statistically correlated with various clinical, histopathological, virological, and genetic parameters.
RESULTS
SVR was significantly associated with the CC and AA alleles of rs12979860 (p = 0.008) and rs12980275 (p = 0.004), respectively. Moreover, albumin levels (p = 0.002) and platelet count (p = 0.039) showed significant differences in the SVR and No SVR groups. On multivariate analysis, the CC allele of rs12979860 (OR, 2.89; 95 % CI 1.6-6.2, p = 0.006) and albumin levels (OR, 1.2; 95 % CI 1.1-1.4, p = 0.001) independently predicted SVR.
CONCLUSIONS
IL28B polymorphism (CC allele of rs12979860) predicts the sustained response to antiviral therapy in HCV-G4.
背景
全基因组关联研究最近发现，白细胞介素（IL）28B基因中的几个单核苷酸多态性（SNP）可预测丙型肝炎病毒（HCV）1型患者对聚乙二醇化干扰素-α2a/b加利巴韦林的持续病毒学应答（SVR）。然而，关于感染HCV基因型4（HCV-G4）患者的数据有限。
目的
我们分析了HCV-G4单感染患者队列中IL28B SNP（血液学、生化、病毒学和病理学因素）与SVR的相关性。
患者与方法
从沙特阿拉伯的三个三级医疗中心招募了129例初治的HCV-G4患者。通过聚合酶链反应和DNA测序鉴定了五个IL28B SNP（rs12979860、rs12980275、rs8105790、rs8099917和rs72486680）。SVR与各种临床、组织病理学、病毒学和遗传参数进行统计学关联分析。
结果
SVR分别与rs12979860的CC和AA等位基因（p = 0.008）以及rs12980275的CC和AA等位基因（p = 0.004）显著相关。此外，白蛋白水平（p = 0.002）和血小板计数（p = 0.039）在SVR组和无SVR组中显示出显著差异。多因素分析显示，rs12979860的CC等位基因（OR，2.89；95%CI 1.6 - 6.2，p = 0.006）和白蛋白水平（OR，1.2；95%CI 1.1 - 1.4，p = 0.001）独立预测SVR。
结论
IL28B多态性（rs1297986O的CC等位基因）可预测HCV-G4患者对抗病毒治疗的持续应答。
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