Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520-8023, USA.
J Interferon Cytokine Res. 2010 Aug;30(8):585-90. doi: 10.1089/jir.2010.0060.
Approximately 500 million people worldwide are chronically infected with the hepatitis B virus (HBV) or hepatitis C virus (HCV), and are therefore at an increased risk for developing fatal liver diseases such as cirrhosis and hepatocellular carcinoma. The intracellular antiviral responses induced by interferon (IFN)-alpha/-beta and/or IFN-gamma play critical roles in the pathogenesis of HBV and HCV infection, and the function of IFN-lambda in the host immune response to these viruses is beginning to be revealed. A better understanding of how IFN-lambda influences HBV or HCV persistence is not only important for understanding the mechanisms of chronic virus infection, but also may lead to new approaches for improved antiviral therapies.
全球约有 5 亿人慢性感染乙型肝炎病毒（HBV）或丙型肝炎病毒（HCV），因此患肝硬化和肝细胞癌等致命肝脏疾病的风险增加。干扰素（IFN）-α/-β和/或 IFN-γ诱导的细胞内抗病毒反应在 HBV 和 HCV 感染的发病机制中起关键作用，IFN-λ在宿主对这些病毒的免疫反应中的功能开始被揭示。更好地了解 IFN-λ如何影响 HBV 或 HCV 的持续存在，不仅对于理解慢性病毒感染的机制很重要，而且可能为改进抗病毒治疗开辟新途径。
