干扰素 lambda 在乙型肝炎病毒和丙型肝炎病毒免疫反应中的作用。
Interferon-lambda in the immune response to hepatitis B virus and hepatitis C virus.
机构信息
Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520-8023, USA.
出版信息
J Interferon Cytokine Res. 2010 Aug;30(8):585-90. doi: 10.1089/jir.2010.0060.
Abstract
Approximately 500 million people worldwide are chronically infected with the hepatitis B virus (HBV) or hepatitis C virus (HCV), and are therefore at an increased risk for developing fatal liver diseases such as cirrhosis and hepatocellular carcinoma. The intracellular antiviral responses induced by interferon (IFN)-alpha/-beta and/or IFN-gamma play critical roles in the pathogenesis of HBV and HCV infection, and the function of IFN-lambda in the host immune response to these viruses is beginning to be revealed. A better understanding of how IFN-lambda influences HBV or HCV persistence is not only important for understanding the mechanisms of chronic virus infection, but also may lead to new approaches for improved antiviral therapies.
摘要
全球约有 5 亿人慢性感染乙型肝炎病毒（HBV）或丙型肝炎病毒（HCV），因此患肝硬化和肝细胞癌等致命肝脏疾病的风险增加。干扰素（IFN）-α/-β和/或 IFN-γ诱导的细胞内抗病毒反应在 HBV 和 HCV 感染的发病机制中起关键作用，IFN-λ在宿主对这些病毒的免疫反应中的功能开始被揭示。更好地了解 IFN-λ如何影响 HBV 或 HCV 的持续存在，不仅对于理解慢性病毒感染的机制很重要，而且可能为改进抗病毒治疗开辟新途径。
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