血清同型半胱氨酸作为冠心病的一个风险因素。

Serum homocysteine as a risk factor for coronary heart disease.

作者信息

Naureen Ayesha, Munazza Bibi, Shaheen Robina, Khan Shahbaz Ali, Fatima Fozia

机构信息

Department of Biochemistry, Ayub Medical College, Abbottabad, Pakistan.

出版信息

J Ayub Med Coll Abbottabad. 2012 Jan-Mar;24(1):59-62.

PMID:23855097

Abstract

BACKGROUND

Homocysteine (Hcy) is an intermediate formed during the catabolism of sulphur containing essential amino acid, methionine and Less than one percent of tHcy is found as the free form. Development of atherosclerotic changes and thrombo-embolism are common features in patients with homocysteinuria. This study was conducted to assess the relationship of Hcy and coronary heart disease (CHD) in our population.

METHODS

The cross-sectional analytical study was carried out at the Department of Biochemistry, Hazara University Mansehra and Ayub Medical College, Abbottabad. A total of 80 subjects were included in this study and were divided into 2 groups. Cases Group consisted of 40 patients who had confirmed Myocardial Infarction (MI) coming for routine follow-up (first re-visit) after the acute attack. Control Group consisted of 40 matching healthy individuals. Demographic data including age, gender, dietary habits, height and weight as documented in preformed proforma. Blood pressure was taken in sitting posture. Serum total Hcy were measured. Data was entered into computer using SPSS 16.0 for analysis.

RESULTS

The mean age of the cases was 59.68 +/- 8.06 (30-70) years and that of the controls was 58.93 +/- 6.93 (48-76) years. The average BMI of cases was 27.70 +/- 3.61 Kg/m2 and of the controls was 25.66 +/- 2.98 Kg/m2. This increase of BMI from controls to cases was statistically significant (p < 0.050). The mean systolic BP of the cases was 153.88 +/- 11.90 mmHg in comparison with 142.62 +/- 11.65 mmHg for the controls. This difference was statistically significant (p < 0.001). Mean tHcy level of the cases was 17.15 +/- 4.45 micromol/l while that of controls was 12.20 +/- 2.53 micromol/l. There is a statistically significant difference between cases and controls with respect to Hcy levels (p < 0.001).

CONCLUSION

Plasma tHcy level has a powerful predictor value of CHD and routine screening for elevated Hcy concentrations is advisable especially for individuals who manifest atherothrombotic disease without their traditional risk factors.

摘要

背景

同型半胱氨酸（Hcy）是含硫必需氨基酸蛋氨酸分解代谢过程中形成的一种中间产物，且发现游离形式的总同型半胱氨酸（tHcy）占比不到1%。同型胱氨酸尿症患者常见动脉粥样硬化改变和血栓栓塞形成。本研究旨在评估我国人群中Hcy与冠心病（CHD）的关系。

方法

本横断面分析研究在哈扎拉大学曼塞赫拉分校生物化学系和阿伯塔巴德阿尤布医学院开展。本研究共纳入80名受试者，分为2组。病例组由40例确诊心肌梗死（MI）且在急性发作后前来进行常规随访（首次复诊）的患者组成。对照组由40名匹配的健康个体组成。人口统计学数据包括年龄、性别、饮食习惯、身高和体重，已记录在预先设计的表格中。采用坐姿测量血压。检测血清总Hcy水平。使用SPSS 16.0将数据录入计算机进行分析。

结果

病例组的平均年龄为59.68±8.06（30 - 70）岁，对照组为58.93±6.93（48 - 76）岁。病例组的平均体重指数（BMI）为27.70±3.61 Kg/m²，对照组为25.66±2.98 Kg/m²。从对照组到病例组，BMI的这种增加具有统计学意义（p < 0.050）。病例组的平均收缩压为153.88±11.90 mmHg，而对照组为142.62±11.65 mmHg。这种差异具有统计学意义（p < 0.001）。病例组的平均tHcy水平为17.15±4.45微摩尔/升，而对照组为12.20±2.53微摩尔/升。病例组和对照组在Hcy水平方面存在统计学显著差异（p < 0.001）。