Liu Weijing, Wang Tao, Sun Pengfei, Zhou Yanju
Department of Emergency, Weifang People's Hospital, Weifang, Shandong 261000, P.R. China.
Exp Ther Med. 2019 Mar;17(3):1756-1760. doi: 10.3892/etm.2018.7111. Epub 2018 Dec 18.
Expression of homocysteine (Hcy) and blood lipid levels in serum of atherosclerotic coronary heart disease (CHD) patients was investigated and the related risk factors were analyzed. A total of 148 CHD patients were selected as study group and another 120 healthy people attending Weifang People's Hospital for physical examination in the same period as control group. Hcy and blood lipid levels in serum were measured in the two groups, including total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). At the same time, analysis of risk factors for CHD was performed. The levels of Hcy, TC, TG and LDL-C in patients in the study group were significantly higher than that in control group, while the HDL-C level was significantly lower than that in control group, and the differences were statistically significant (P<0.001). The difference was statistically significant in the levels of Hcy, TC, TG and LDL-C between acute and old myocardial infarction and angina pectoris group (P<0.05), and the difference was statistically significant in the levels of Hcy, TC, TG and LDL-C between old and acute myocardial infarction group (P<0.05). Analysis of risk factors for the disease was performed using logistic regression. The results of univariate analysis showed that CHD was associated with Hcy, hyperlipidemia, smoking, hypertension and diabetes (P<0.05), but had no relationship with drinking and obesity (P>0.05). The results of multivariate analysis showed that Hcy, hyperlipidemia, hypertension and diabetes were independent risk factors for CHD, and the difference was statistically significant (P<0.05). The Hcy level increased and the HDL-C level decreased in serum of CHD patients. Hcy, hyperlipidemia, hypertension and diabetes are independent risk factors for CHD, which can provide practical basis for the diagnosis, treatment and prevention.
研究了动脉粥样硬化性冠心病（CHD）患者血清中同型半胱氨酸（Hcy）的表达及血脂水平，并分析相关危险因素。选取148例CHD患者作为研究组，另选取同期在潍坊市人民医院进行体检的120例健康人作为对照组。检测两组血清中的Hcy和血脂水平，包括总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）。同时，对CHD的危险因素进行分析。研究组患者的Hcy、TC、TG和LDL-C水平显著高于对照组，而HDL-C水平显著低于对照组，差异具有统计学意义（P<0.001）。急性心肌梗死与陈旧性心肌梗死及心绞痛组之间Hcy、TC、TG和LDL-C水平差异具有统计学意义（P<0.05），陈旧性心肌梗死组与急性心肌梗死组之间Hcy、TC、TG和LDL-C水平差异具有统计学意义（P<0.05）。采用逻辑回归分析该疾病的危险因素。单因素分析结果显示，CHD与Hcy、高脂血症、吸烟、高血压和糖尿病有关（P<0.05），但与饮酒和肥胖无关（P>0.05）。多因素分析结果显示，Hcy、高脂血症、高血压和糖尿病是CHD的独立危险因素，差异具有统计学意义（P<0.05）。CHD患者血清中Hcy水平升高，HDL-C水平降低。Hcy、高脂血症、高血压和糖尿病是CHD的独立危险因素，可为诊断、治疗和预防提供实践依据。
