Laboratoire des Biomolécules et de l'Environnement (LCBE), Université de Perpignan Via Domitia, centre de phytopharmacie, 58 avenue P. Alduy, 66860 Perpignan, France.
Org Lett. 2013 Aug 2;15(15):3898-901. doi: 10.1021/ol401645m. Epub 2013 Jul 15.
The first total synthesis of laxaphycin B was accomplished through stepwise automated Solid Phase Peptide Synthesis (SPPS), leading to the structural revision of its stereochemistry especially with regard to the configuration of one of the two 3-hydroxyleucines of this cyclic dodecapeptide of marine origin. The analogous Lyngbyacyclamide A was obtained by an extension of this synthesis.
通过逐步自动化的固相肽合成（SPPS），实现了 laxaphycin B 的首次全合成，从而对其立体化学结构进行了修订，特别是涉及到这种海洋来源的十二肽中环的两个 3-羟基亮氨酸之一的构型。通过这种合成的扩展，得到了类似的 Lyngbyacyclamide A。
