自由基介导的环形成在超修饰 tRNA 碱基 wybutosine 的生物合成中。
Radical mediated ring formation in the biosynthesis of the hypermodified tRNA base wybutosine.
机构信息
Department of Chemistry and Biochemistry, University of Arizona, 1041 E. Lowell Street, Tucson, AZ 85701, United States.
出版信息
Curr Opin Chem Biol. 2013 Aug;17(4):613-8. doi: 10.1016/j.cbpa.2013.05.035. Epub 2013 Jul 12.
Abstract
Wyosine and its derivatives are highly modified, acid labile tricyclic bases found at position 37 of tRNA(Phe) in archaea and eukarya. The formation of the common 4-demethylwyosine structural feature entails condensation of pyruvate and N-methylguanosine catalyzed by TYW1. This review will focus on the mechanism of this complex radical mediated transformation.
摘要
Wyosine 及其衍生物是高度修饰的、酸不稳定的三环碱基，存在于古菌和真核生物的 tRNA(Phe)的 37 位。常见的 4-去甲基 wyosine 结构特征的形成需要 TYW1 催化丙酮酸和 N-甲基鸟苷的缩合。这篇综述将重点介绍这种复杂的自由基介导转化的机制。
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