State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
Fitoterapia. 2013 Oct;90:30-7. doi: 10.1016/j.fitote.2013.07.005. Epub 2013 Jul 13.
A phytochemical study on the ethanolic extract of the stem barks of Uncaria laevigata leads to the isolation and characterization of 18 triterpenoid compounds. Ten of these are new, including one novel heptanortriterpenoid (1), four ursane triterpenes (2-4, 10), and five oleanane triterpenes (5-9). Their structures were established by spectroscopic methods, especially by 2D-NMR and MS analyses. All these isolates were evaluated for their inhibitory effects on α-glucosidase: ursolic acid and 3 showed potent activities with IC₅₀ values of 16 ± 2.2 and 49 ± 3.7 μM, respectively.
从钩藤茎皮的乙醇提取物中进行植物化学研究，导致分离和鉴定出 18 种三萜类化合物。其中有 10 种是新的，包括一种新型庚烷三萜（1）、四种熊果酸三萜（2-4、10）和五种齐墩果烷三萜（5-9）。它们的结构通过光谱方法，特别是二维 NMR 和 MS 分析确定。所有这些分离物均评估了其对α-葡萄糖苷酶的抑制作用：熊果酸和 3 显示出很强的活性，IC₅₀ 值分别为 16 ± 2.2 和 49 ± 3.7 μM。
