School of Pharmacy, College of Medicine, National Taiwan University, Taipei 10051, Taiwan, ROC.
Phytochemistry. 2012 Feb;74:206-11. doi: 10.1016/j.phytochem.2011.09.016. Epub 2011 Dec 12.
Triterpenoids, 1-3, 8 and 9, along with 24 known compounds were isolated from leaves and twigs of Fagus hayatae. Of these, compound 1, 1,10-seco-3β,10α,23-trihydroxyolean-12-ene-1,28-dioic acid 1,23-lactone, possesses a hitherto unknown 1,10-seco-oleanane skeleton. In addition, 2,3-seco-20(29)-lupene-2,3-dioic acid (16), previously described as a synthetic product, is now established as a plant natural product; the neolignan-9'-O-rhamnoside 19 is also characterized herein. Their structures were deduced mainly by 1D and 2D NMR spectroscopic analyses. Seven of these compounds possess moderate inhibitory activity against α-glucosidase type IV (Bacillus stearothermophilus).
从台湾水青冈的叶和小枝中分离得到了三萜类化合物 1-3、8 和 9，以及 24 种已知化合物。其中，化合物 1，1,10-断-3β,10α,23-三羟基齐墩烷-12-烯-1,28-二酸 1,23-内酯，具有以前未知的 1,10-断齐墩烷骨架。此外，2,3-断-20(29)-羽扇豆烯-2,3-二酸（16），以前被描述为合成产物，现在被确定为植物天然产物；新木脂素-9'-O-鼠李糖苷 19 也在此文中得到了表征。它们的结构主要通过 1D 和 2D NMR 光谱分析推断得出。其中 7 种化合物对 α-葡萄糖苷酶 IV（嗜热脂肪芽孢杆菌）具有中等抑制活性。
