Albert D J, Jonik R H, Walsh M L
Psychology Department, University of British Columbia, Vancouver, Canada.
Physiol Behav. 1990 Apr;47(4):699-703. doi: 10.1016/0031-9384(90)90080-n.
Female hooded rats (250 to 325 g) were ovariectomized and bilaterally implanted with testosterone-filled or empty Silastic tubes. The testosterone-filled space in each tube was 10 mm long and this should produce a serum testosterone concentration 4 to 5 times that of an intact female, but well below that of a male. Three weeks following surgery, half of the animals with testosterone implants were housed with an animal with an empty implant and left for 6 weeks. The remaining animals were placed on a 23-hr food deprivation schedule, housed in testosterone implant/empty implant pairs, and then subjected to a series of food competition tests. Following the competition tests, all animals were individually tested in their living cage for aggression toward an unfamiliar female. In food competition, females with testosterone implants were more successful and more aggressive than their cagemates with empty implants. When tested for aggression toward an unfamiliar intruder, females with testosterone implants given competitive experience were more aggressive toward an intruder than were their cagemates with empty implants or females with testosterone implants not given the competitive experience. Females with testosterone implants but without competitive experience were not more aggressive toward an unfamiliar female than were their cagemates with empty implants. These results suggest that, in ovariectomized females with testosterone implants, hormone-dependent aggression fostered by a competitive situation is displayed toward unfamiliar females.
雌性带帽大鼠（体重250至325克）接受双侧卵巢切除术，并双侧植入填充睾酮或空的硅橡胶管。每根管中填充睾酮的部分长10毫米，这应使血清睾酮浓度达到完整雌性大鼠的4至5倍，但远低于雄性大鼠。手术后三周，一半植入睾酮的动物与植入空管的动物饲养在一起，持续6周。其余动物按照23小时禁食方案饲养，成对放置，一只植入睾酮，一只植入空管，然后进行一系列食物竞争测试。竞争测试后，所有动物在其生活笼中单独接受测试，以检测其对陌生雌性的攻击性。在食物竞争中，植入睾酮的雌性大鼠比植入空管的同笼伙伴更成功、更具攻击性。在测试对陌生入侵者的攻击性时，有竞争经验的植入睾酮的雌性大鼠比植入空管的同笼伙伴或没有竞争经验的植入睾酮的雌性大鼠对入侵者更具攻击性。没有竞争经验的植入睾酮的雌性大鼠对陌生雌性的攻击性并不比植入空管的同笼伙伴更强。这些结果表明，在植入睾酮的去卵巢雌性大鼠中，竞争情境促进的激素依赖性攻击行为会针对陌生雌性表现出来。
