Blokland A, Raaijmakers W, van der Staay F J, Jolles J
Department of Neuropsychology and Psychobiology, University of Limburg, Maastricht, The Netherlands.
Physiol Behav. 1990 Apr;47(4):783-5. doi: 10.1016/0031-9384(90)90096-m.
Acetyl-l-carnitine (ALCAR) exerts antiaging effects with study we evaluated the effect of a chronic treatment with ALCAR (6 weeks, 50 mg/kg/day) on the open field behavior of 5-month-old and 26-month-old male Wistar rats. Old rats defecated more, made fewer crossings, and spent more time in the corner squares. However, it is difficult to interpret these findings in terms of an increase in emotional reactivity with age because locomotor performance generally has been found to be impaired in old rats. Consequently, treatment effects were analysed within age groups. ALCAR had no effect in young rats, but the old ALCAR-treated rats ambulated less and spent more time in the corner squares than the old control rats. We have interpreted this in terms of an enhanced emotional reactivity of old ALCAR-treated rats.
乙酰左旋肉碱（ALCAR）具有抗衰老作用。在本研究中，我们评估了用ALCAR（6周，50毫克/千克/天）长期治疗对5月龄和26月龄雄性Wistar大鼠旷场行为的影响。老年大鼠排便更多，穿越次数更少，在角落方格中停留的时间更长。然而，由于一般发现老年大鼠的运动能力受损，因此很难从随着年龄增长情绪反应性增加的角度来解释这些发现。因此，在各年龄组内分析治疗效果。ALCAR对年轻大鼠没有影响，但与老年对照大鼠相比，接受ALCAR治疗的老年大鼠走动较少，在角落方格中停留的时间更长。我们将此解释为接受ALCAR治疗的老年大鼠情绪反应性增强。
