Kohjimoto Y, Ogawa T, Matsumoto M, Shirakawa K, Kuwaki T, Yasuda H, Anami K, Fujii T, Satoh H, Ono T
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan.
Jpn J Pharmacol. 1988 Nov;48(3):365-71. doi: 10.1254/jjp.48.365.
The effects of long-term dosing with acetyl-L-carnitine (ALC) were examined in aged rats, and they were compared with those in young rats. ALC significantly reduced the lipofuscin deposition in the brain of aged rats. Emotional parameters such as locomotor activity and rearing behavior are lower in aged rats than in young rats, and these behaviors decreased in both age groups during the experiments. ALC diminished the decrease of these emotional behaviors, especially in rearing behavior in the aged rats. Furthermore, ALC had no effect on body weight gain. These results might reflect one of the main beneficial pharmacological mechanisms of ALC in clinical use.
研究了长期给予乙酰-L-肉碱（ALC）对老年大鼠的影响，并将其与年轻大鼠的影响进行了比较。ALC显著减少了老年大鼠大脑中的脂褐素沉积。老年大鼠的运动活动和竖毛行为等情绪参数低于年轻大鼠，并且在实验过程中两个年龄组的这些行为均有所下降。ALC减轻了这些情绪行为的下降，尤其是老年大鼠的竖毛行为。此外，ALC对体重增加没有影响。这些结果可能反映了ALC在临床应用中的主要有益药理机制之一。
