Amenta F, Ferrante F, Lucreziotti R, Ricci A, Ramacci M T
Dipartimento di Scienze Neurologiche, Università La Sapienza, Rome, Italy.
Arch Gerontol Geriatr. 1989 Sep-Oct;9(2):147-53. doi: 10.1016/0167-4943(89)90035-6.
By using fluorescence microscopy and microfluorimetric techniques, the effects of ageing and of 11 months acetyl-L-carnitine (ALCAR) treatment on lipofuscin deposition within the cytoplasm of pyramidal neurons of rat prefrontal cortex and hippocampus (CA3 field) were assessed. No lipofuscin autofluorescence was observed in the nerve cell bodies of neurons under study in young rats (3 months of age), but lipopigment had accumulated in the same nerve cells of senescent rats (22 months of age). ALCAR administration significantly reduced the accumulation of lipofuscin within pyramidal neurons of the brain areas examined.
通过使用荧光显微镜和微量荧光测定技术，评估了衰老以及11个月乙酰-L-肉碱（ALCAR）治疗对大鼠前额叶皮质和海马体（CA3区）锥体细胞胞质内脂褐素沉积的影响。在年轻大鼠（3个月大）的研究神经元的神经细胞体中未观察到脂褐素自发荧光，但在衰老大鼠（22个月大）的相同神经细胞中已积累了脂色素。给予ALCAR可显著减少所检查脑区锥体细胞内脂褐素的积累。
