在为增强胆碱能功能而选择性培育的大鼠中，主动回避反应受损。
Impaired active avoidance responding in rats selectively bred for increased cholinergic function.
作者信息
Overstreet D H, Rezvani A H, Janowsky D S
机构信息
Center for Alcohol Studies, School of Medicine, University of North Carolina, Chapel Hill 27514.
出版信息
Physiol Behav. 1990 Apr;47(4):787-8. doi: 10.1016/0031-9384(90)90097-n.
PMID:2385654
Abstract
It was found that the Flinders Sensitive Line (FSL) of rat, selectively bred for increased cholinergic function, performed poorly in a tone-cued two-way active avoidance task in comparison with the control Flinders Restraint Line (FRL) of rat. These findings are consistent with the suggestion that the FSL rats may be a genetic animal model of depression.
摘要
研究发现，为增强胆碱能功能而经选择性培育的大鼠弗林德斯敏感系（FSL），与对照大鼠弗林德斯抗性系（FRL）相比，在音调提示双向主动回避任务中表现较差。这些发现与FSL大鼠可能是抑郁症基因动物模型这一观点相一致。
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