Sirtuins 作为 ALS 的治疗靶点。
Sirtuins as therapeutic targets of ALS.
机构信息
Department of Neurology, Mount Sinai School of Medicine, 1468 Madison Avenue, Annenberg Building, Room 20-02, New York, NY 10029, USA.
出版信息
Cell Res. 2013 Sep;23(9):1073-4. doi: 10.1038/cr.2013.94. Epub 2013 Jul 16.
Abstract
Sirtuins have received a lot of attention in biological functions associated with metabolism, survival development, and most recently, neurodegeneration. The versatile role of sirtuins can be readily redirected for drug discovery studies for novel treatment in amyotrophic lateral sclerosis (ALS), as presented in this highlight, by sirtuin-mediated ketogenic responses influencing mitochondrial function.
摘要
Sirtuins 受到了广泛关注，它们与代谢、生存发育以及最近的神经退行性疾病有关。正如本亮点所述，Sirtuins 的多功能作用可以很容易地重新用于药物发现研究，以寻找肌萎缩侧索硬化症 (ALS) 的新治疗方法，即 Sirtuins 介导的生酮反应影响线粒体功能。
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