Skin Laboratory, Sullivan Nicolaides Pathology, Indooroopilly, Australia.
Pathology. 2013 Aug;45(5):489-91. doi: 10.1097/PAT.0b013e32836326a1.
To study the histological features of a large series of patients with chromoblastomycosis to ascertain whether the earlier presentation of patients with this disease has resulted in any changes in the histological features that were recorded over 60 years ago.
A key word search of the database of our pathology laboratory over the period 1 January 2004 to 30 June 2012 was carried out for cases reported as chromoblastomycosis.
Seventy cases of chromoblastomycosis were reported over this period. A further four cases of subcutaneous chromomycosis were found in this search. They were excluded from the study because of their different aetiopathogenesis. Key histological features such as the presence of pseudoepitheliomatous hyperplasia, granulomas, suppurative granulomas, suppuration and the presence of brown (dematiaceous) sclerotic bodies were evaluated. Fewer cases showed pseudoepitheliomatous hyperplasia than in earlier studies. Sclerotic bodies were found easily in H&E sections in all cases, averting the need for any special stains. Only ten cases were submitted for culture; six grew Cladophialophora carionii and two Fonsecaea pedrosoi.
Chromoblastomycosis has changed little, histologically, since the original descriptions over 60 years ago, despite its much earlier clinical presentation these days. Pseudoepitheliomatous hyperplasia was seen in 77.1% of our cases, compared to its almost universal presence in cases reported many years ago that often presented after many years with the disease.
研究大系列着色芽生菌病患者的组织学特征，以确定该病患者的早期表现是否导致 60 多年前记录的组织学特征发生任何变化。
对 2004 年 1 月 1 日至 2012 年 6 月 30 日期间我们病理实验室数据库进行关键字搜索，查找报告为着色芽生菌病的病例。
在此期间报告了 70 例着色芽生菌病。在此次搜索中还发现了另外 4 例皮下暗色丝孢霉病。由于它们的病因不同，因此将其排除在研究之外。评估了关键的组织学特征，如假性上皮瘤样增生、肉芽肿、化脓性肉芽肿、化脓和存在棕色（暗色）硬化体。与早期研究相比，假性上皮瘤样增生的病例较少。在所有病例中，H&E 切片中很容易发现硬化体，避免了任何特殊染色的需要。只有 10 例进行了培养；6 例培养出卡氏枝孢霉，2 例培养出佩氏利什曼原虫。
尽管如今该病的临床表现要早得多，但从 60 多年前的原始描述以来，着色芽生菌病在组织学上几乎没有变化。我们的病例中 77.1%可见假性上皮瘤样增生，而多年前报告的病例中几乎普遍存在，这些病例往往在患病多年后才出现。
