骨关节炎：骨质疏松性骨关节炎：骨作用药物的合理靶点。
Osteoarthritis: Osteoporotic OA: a reasonable target for bone-acting agents.
出版信息
Nat Rev Rheumatol. 2013 Aug;9(8):448-50. doi: 10.1038/nrrheum.2013.113. Epub 2013 Jul 16.
PMID:23857129
Abstract
Beneficial effects of bone-acting drugs in osteoarthritis (OA) are increasingly reported, but reliable conclusions regarding their efficacy are hindered by methodological drawbacks in study design. Identifying patients with osteoporotic OA, a phenotype defined by decreased density associated with high remodelling in subchondral bone, might improve the success of bone-directed agents.
摘要
骨作用药物在骨关节炎（OA）中的有益作用越来越多地被报道，但由于研究设计中的方法学缺陷，对其疗效的可靠结论受到阻碍。确定患有骨质疏松性 OA 的患者，这种表型的特征是与软骨下骨高重塑相关的骨密度降低，可能会提高骨靶向药物的疗效。
Zotero 插件