State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS), Changchun 130022, China.
Biomaterials. 2013 Oct;34(31):7715-24. doi: 10.1016/j.biomaterials.2013.06.045. Epub 2013 Jul 13.
Theranostics, the integration of diagnostics and therapies, has become a new concept in the battles with various major diseases such as cancer. Here, we report a multifunctional nanoplatform, which is developed by covalently grafting core-shell structured upconversion nanoparticles (UCNPs) with nanographene oxide (NGO) via bifunctional polyethylene glycol (PEG), and then loading phthalocyanine (ZnPc) on the surface of NGO. The obtained UCNPs-NGO/ZnPc nanocomposites are not only be used as upconversion luminescence (UCL) imaging probes of cells and whole-body animals with high contrast for diagnosis, but also can generate cytotoxic singlet oxygen under light excitation for photodynamic therapy (PDT), as well as rapidly and efficiently convert the 808 nm laser energy into thermal energy for photothermal therapy (PTT). A remarkably improved and synergistic therapeutic effect compared to PTT or PDT alone is obtained, providing high therapeutic efficiency for cancer treatment. Therefore, benefiting from the unique multifunctional hybrid nanostructure, UCNPs-NGO/ZnPc nanocomposites developed herein are promising as an integrated theranostic probe for potential UCL image-guided combinatorial PDT/PTT of cancer.
治疗诊断一体化（Theranostics）已经成为对抗癌症等多种重大疾病的新理念。在这里，我们报告了一种多功能纳米平台，该平台通过双功能聚乙二醇（PEG）将核壳结构的上转换纳米粒子（UCNPs）共价接枝到纳米氧化石墨烯（NGO）上，然后在 NGO 表面负载酞菁锌（ZnPc）。所得到的 UCNPs-NGO/ZnPc 纳米复合材料不仅可以用作细胞和整体动物的上转换发光（UCL）成像探针，具有高对比度用于诊断，而且可以在光激发下产生细胞毒性单线态氧用于光动力治疗（PDT），以及快速有效地将 808nm 激光能量转化为用于光热治疗（PTT）的热能。与单独的 PTT 或 PDT 相比，获得了显著改善和协同的治疗效果，为癌症治疗提供了高效的治疗效果。因此，得益于独特的多功能混合纳米结构，本文所开发的 UCNPs-NGO/ZnPc 纳米复合材料有望成为一种用于癌症的 UCL 图像引导联合 PDT/PTT 的集成治疗诊断探针。
