Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin, 150001, China.
Dalton Trans. 2018 Mar 12;47(11):3931-3939. doi: 10.1039/c7dt04141a.
NIR light-induced imaging-guided cancer therapy is an encouraging route in the cancer theranostic field. Herein, we describe a novel nanoscale proposal, which is established by covalently implanting core-shell structured upconversion nanoparticles (UCNPs) with nanographene oxide (NGO) by a process utilizing polyethylene glycol (PEG), and consequently loading Chlorin e6 (Ce6) onto the surface of NGO. The acquired NGO-UCNP-Ce6 (NUC) nanocomposites can not only be employed as upconversion luminescence (UCL) imaging probes of cells and whole-body animals with high contrast for diagnosis, but also can generate reactive oxygen species (ROS) under 808 nm light excitation for photodynamic therapy (PDT); over and above, they can swiftly and proficiently translate the 808 nm photon into thermal energy for photothermal therapy (PTT). An extraordinarily enhanced and synchronized therapeutic effect paralleled to the individual PTT or PDT is achieved, rendering extraordinary therapeutic effectiveness for cancer treatment. Consequently, profiting from this inimitable multifunctional nanohybrid, the NUCs synthesized here are encouraging as a cohesive theranostic probe for impending UCL imaging-guided combinatorial PDT/PTT.
近红外光诱导的成像引导癌症治疗是癌症治疗学领域中一个令人鼓舞的途径。在这里，我们描述了一种新的纳米级方案，该方案通过利用聚乙二醇（PEG）的过程，将核壳结构的上转换纳米粒子（UCNPs）共价植入纳米氧化石墨烯（NGO）中，并将氯乙酮（Ce6）负载到 NGO 的表面上。所获得的 NGO-UCNP-Ce6（NUC）纳米复合材料不仅可以用作细胞和全身动物的上转换发光（UCL）成像探针，具有高对比度用于诊断，而且可以在 808nm 光激发下产生活性氧（ROS）用于光动力治疗（PDT）；除此之外，它们可以迅速有效地将 808nm 光子转化为用于光热治疗（PTT）的热能。与单独的 PTT 或 PDT 相比，实现了协同治疗效果的显著增强和同步，为癌症治疗带来了非凡的疗效。因此，得益于这种独特的多功能纳米杂化材料，这里合成的 NUC 作为一种有前途的 UCL 成像引导联合 PDT/PTT 的治疗诊断探针具有广阔的应用前景。
