Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, PR China.
College of Sciences, Heihe University, Heihe, Heilongjiang 164300, PR China.
Inorg Chem. 2020 Apr 6;59(7):4909-4923. doi: 10.1021/acs.inorgchem.0c00170. Epub 2020 Mar 12.
Photodynamic therapy (PDT) is commonly employed in clinics to treat the cancer, but because of the hypoxic tumor microenvironment prevalent inside tumors, PDT therapeutic efficiency is not adequate hence limiting the effectiveness of PDT. Therefore, we designed a nanocomposite consisting of reduced nanographene oxide (rGO) modified with polyethylene glycol (PEG), manganese dioxide (MnO), upconversion nanoparticles (UCNPs), and Chlorin e6 (Ce6) to spark oxygen production from HO with the aim of relieving the tumor hypoxic microenvironments. For tumor PDT and photothermal therapy (PTT), UCNPs-Ce6-labeled rGO-MnO-PEG nanocomposites were used as a therapeutic agent, augmenting the therapeutic efficiency of PDT via redox progression through the catalytic HO decomposition pathway and further achieving excellent tumor inhibition. It is important to mention that degradation of MnO in an acidic cellular microenvironment leads to the creation of a massive volume of Mn which was employed as a contrast mediator for magnetic resonance imaging (MRI). Our research postulates an approach to spark O formation through an internal stimulus to augment the efficiency of MRI- and computerized tomography (CT)-imaging-guided PDT and PTT.
光动力疗法（PDT）常用于临床治疗癌症，但由于肿瘤内普遍存在缺氧的肿瘤微环境，PDT 的治疗效率不足，从而限制了 PDT 的效果。因此，我们设计了一种由还原氧化石墨烯（rGO）与聚乙二醇（PEG）、二氧化锰（MnO）、上转换纳米粒子（UCNPs）和氯乙锭（Ce6）组成的纳米复合材料，旨在通过 HO 产生氧气，以缓解肿瘤缺氧微环境。用于肿瘤 PDT 和光热治疗（PTT），UCNPs-Ce6 标记的 rGO-MnO-PEG 纳米复合材料被用作治疗剂，通过氧化还原进展通过催化 HO 分解途径增强 PDT 的治疗效率，并进一步实现优异的肿瘤抑制。值得注意的是，MnO 在酸性细胞微环境中的降解导致大量 Mn 的产生，Mn 被用作磁共振成像（MRI）的对比剂。我们的研究提出了一种通过内部刺激产生 O 的方法，以提高 MRI 和计算机断层扫描（CT）成像引导的 PDT 和 PTT 的效率。
