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一例阿莫西林诱发的伴有胆管损伤的肝细胞性肝损伤。

A case of amoxicillin-induced hepatocellular liver injury with bile-duct damage.

作者信息

Kim Ju Seung, Jang Young Rock, Lee Ji Won, Kim Jin Yong, Jung Young Kul, Chung Dong Hae, Kwon Oh Sang, Kim Yun Soo, Choi Duck Joo, Kim Ju Hyun

机构信息

Department of Internal Medicine, Gachon University Gil Hospital, Gachon University of Medicine and Science, Incheon, Korea.

出版信息

Korean J Hepatol. 2011 Sep;17(3):229-32. doi: 10.3350/kjhep.2011.17.3.229.

DOI:10.3350/kjhep.2011.17.3.229
PMID:22102391
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3304646/
Abstract

Amoxicillin, an antibiotic that is widely prescribed for various infections, is associated with a very low rate of drug-induced liver injury; hepatitis and cholestasis are rare complications. Here we present a case of a 39-year-old woman who was diagnosed with abdominal actinomycosis and received amoxicillin treatment. The patient displayed hepatocellular and bile-duct injury, in addition to elevated levels of liver enzymes. The patient was diagnosed with amoxicillin-induced cholestatic hepatitis. When amoxicillin was discontinued, the patient's symptoms improved and her liver enzyme levels reduced to near to the normal range.

摘要

阿莫西林是一种广泛用于治疗各种感染的抗生素，其药物性肝损伤发生率极低；肝炎和胆汁淤积是罕见的并发症。在此，我们报告一例39岁女性患者，她被诊断为腹部放线菌病并接受了阿莫西林治疗。该患者除肝酶水平升高外，还出现了肝细胞和胆管损伤。患者被诊断为阿莫西林诱发的胆汁淤积性肝炎。停用阿莫西林后，患者症状改善，肝酶水平降至接近正常范围。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e20/3304646/29e718da9005/kjhep-17-229-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e20/3304646/cfe59fc0b316/kjhep-17-229-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e20/3304646/29e718da9005/kjhep-17-229-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e20/3304646/cfe59fc0b316/kjhep-17-229-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e20/3304646/29e718da9005/kjhep-17-229-g002.jpg

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