• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

螺旋藻（Hassall）Kützing 提取物对实验性 2 型糖尿病大鼠的抗氧化和肾保护作用。

Antioxidant and renoprotective effects of Spirogyra neglecta (Hassall) Kützing extract in experimental type 2 diabetic rats.

机构信息

Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.

出版信息

Biomed Res Int. 2013;2013:820786. doi: 10.1155/2013/820786. Epub 2013 Jun 3.

DOI:10.1155/2013/820786
PMID:23862157
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3686068/
Abstract

Spirogyra neglecta extract (SNE) has shown antihyperglycemia and antihyperlipidemia in type 2 diabetic mellitus (T2DM) rats. This study investigated the antioxidant and renoprotective effects of SNE in T2DM rats induced by high-fat diet with low-single dose streptozotocin. T2DM rats were fed daily with SNE (0.25, 0.5, and 1 g/kg BW) for 12 weeks. Renal morphology, malondialdehyde levels, qPCR, and western blotting were analyzed. Renal cortical slices were used to determine renal transport of organic anions, which are estrone sulfate and para-aminohippurate, mediated through organic anion transporter 3-Oat3. Insulin and PKCζ were known to activate Oat3 function while it was inhibited by PKCα. Compared to T2DM, plasma glucose, triglyceride, insulin resistance, renal morphology, and malondialdehyde levels were significantly improved by SNE supplementation. Reduced glutathione peroxidase and nuclear factor κB expressions were related to antioxidant effect of SNE. Oat3 mRNA and protein were not different among groups, but insulin-stimulated rOat3 followed by anion uptakes was abolished in T2DM. This was restored in the slices from SNE treatment. The mechanism of SNE-improved Oat3 was associated with PKCα and PKCζ expressions and activities. These findings indicate that SNE has beneficial effects on renal transport through antioxidant enzymes and PKCs in T2DM rats.

摘要

neglecta 螺旋藻提取物 (SNE) 已显示出在 2 型糖尿病 (T2DM) 大鼠中具有降血糖和降血脂作用。本研究探讨了高脂肪饮食联合低剂量链脲佐菌素诱导的 T2DM 大鼠中 SNE 的抗氧化和肾保护作用。T2DM 大鼠每日用 SNE(0.25、0.5 和 1 g/kg BW) 治疗 12 周。分析了肾脏形态、丙二醛水平、qPCR 和 Western 印迹。使用肾脏皮质切片来确定通过有机阴离子转运蛋白 3-Oat3 介导的雌酮硫酸盐和对氨基马尿酸盐的肾脏有机阴离子转运。胰岛素和蛋白激酶 Cζ (PKCζ) 已知可激活 Oat3 功能，而蛋白激酶 Cα (PKCα) 则抑制其功能。与 T2DM 相比，SNE 补充可显著改善血浆葡萄糖、甘油三酯、胰岛素抵抗、肾脏形态和丙二醛水平。还原型谷胱甘肽过氧化物酶和核因子 κB 的表达与 SNE 的抗氧化作用有关。各组之间 Oat3 mRNA 和蛋白没有差异，但 T2DM 大鼠中胰岛素刺激的 rOat3 随后的阴离子摄取被阻断，而 SNE 治疗的切片中则恢复了这一作用。SNE 改善 Oat3 的机制与 PKCα 和 PKCζ 的表达和活性有关。这些发现表明，SNE 通过抗氧化酶和 PKC 在 T2DM 大鼠中对肾脏转运具有有益作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/3686068/fa5565701a73/BMRI2013-820786.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/3686068/a39a3038151e/BMRI2013-820786.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/3686068/e10e5b3060b1/BMRI2013-820786.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/3686068/a2cfc0850705/BMRI2013-820786.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/3686068/b2e297a3e405/BMRI2013-820786.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/3686068/f96d3f035d00/BMRI2013-820786.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/3686068/5bc1111bed15/BMRI2013-820786.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/3686068/66603d176da1/BMRI2013-820786.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/3686068/84e2958e9205/BMRI2013-820786.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/3686068/fa5565701a73/BMRI2013-820786.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/3686068/a39a3038151e/BMRI2013-820786.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/3686068/e10e5b3060b1/BMRI2013-820786.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/3686068/a2cfc0850705/BMRI2013-820786.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/3686068/b2e297a3e405/BMRI2013-820786.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/3686068/f96d3f035d00/BMRI2013-820786.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/3686068/5bc1111bed15/BMRI2013-820786.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/3686068/66603d176da1/BMRI2013-820786.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/3686068/84e2958e9205/BMRI2013-820786.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/3686068/fa5565701a73/BMRI2013-820786.009.jpg

相似文献

1
Antioxidant and renoprotective effects of Spirogyra neglecta (Hassall) Kützing extract in experimental type 2 diabetic rats.螺旋藻（Hassall）Kützing 提取物对实验性 2 型糖尿病大鼠的抗氧化和肾保护作用。
Biomed Res Int. 2013;2013:820786. doi: 10.1155/2013/820786. Epub 2013 Jun 3.
2
Antidiabetic and renoprotective effects of Cladophora glomerata Kützing extract in experimental type 2 diabetic rats: a potential nutraceutical product for diabetic nephropathy.球状刚毛藻提取物对实验性2型糖尿病大鼠的抗糖尿病和肾脏保护作用：一种治疗糖尿病肾病的潜在营养保健品。
J Diabetes Res. 2015;2015:320167. doi: 10.1155/2015/320167. Epub 2015 Mar 26.
3
Spirogyra neglecta Aqueous Extract Attenuates LPS-Induced Renal Inflammation. neglecta 螺旋藻水提物可减轻 LPS 诱导的肾脏炎症。
Biol Pharm Bull. 2019;42(11):1814-1822. doi: 10.1248/bpb.b19-00199.
4
Decreased renal organic anion transporter 3 expression in type 1 diabetic rats.1 型糖尿病大鼠肾脏有机阴离子转运体 3 表达降低。
Am J Med Sci. 2014 Mar;347(3):221-7. doi: 10.1097/MAJ.0b013e3182831740.
5
Cancer chemopreventive effect of Spirogyra neglecta (Hassall) Kützing on diethylnitrosamine-induced hepatocarcinogenesis in rats.纤细刚毛藻（哈索尔）屈茨对大鼠二乙基亚硝胺诱导的肝癌发生的化学预防作用。
Asian Pac J Cancer Prev. 2014;15(4):1611-6. doi: 10.7314/apjcp.2014.15.4.1611.
6
Beneficial effects of Spirogyra Neglecta Extract on antioxidant and anti-inflammatory factors in streptozotocin-induced diabetic rats.纤细刚毛藻提取物对链脲佐菌素诱导的糖尿病大鼠抗氧化和抗炎因子的有益作用。
Biomol Concepts. 2018 Dec 31;9(1):184-189. doi: 10.1515/bmc-2018-0015.
7
Impaired insulin signaling affects renal organic anion transporter 3 (Oat3) function in streptozotocin-induced diabetic rats.胰岛素信号受损影响链脲佐菌素诱导的糖尿病大鼠的肾脏有机阴离子转运体3（Oat3）功能。
PLoS One. 2014 May 6;9(5):e96236. doi: 10.1371/journal.pone.0096236. eCollection 2014.
8
Riceberry bran extract prevents renal dysfunction and impaired renal organic anion transporter 3 (Oat3) function by modulating the PKC/Nrf2 pathway in gentamicin-induced nephrotoxicity in rats.红米糠提取物通过调节蛋白激酶C/核因子E2相关因子2（PKC/Nrf2）信号通路，预防庆大霉素诱导的大鼠肾毒性中的肾功能障碍及肾脏有机阴离子转运体3（Oat3）功能受损。
Phytomedicine. 2016 Dec 15;23(14):1753-1763. doi: 10.1016/j.phymed.2016.10.014. Epub 2016 Oct 29.
9
Regulation of renal organic anion transporter 3 (SLC22A8) expression and function by the integrity of lipid raft domains and their associated cytoskeleton.脂筏结构域及其相关细胞骨架的完整性对肾有机阴离子转运体3（SLC22A8）表达和功能的调节
Cell Physiol Biochem. 2013;31(4-5):565-78. doi: 10.1159/000350077. Epub 2013 Apr 26.
10
Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice.有机阴离子转运体3（Oat3，即Slc22a8）基因敲除小鼠肾脏和脉络丛中有机阴离子转运受损。
J Biol Chem. 2002 Jul 26;277(30):26934-43. doi: 10.1074/jbc.M203803200. Epub 2002 May 13.

引用本文的文献

1
Kützing extract exhibits antioxidant, anti-inflammation, and anti-nitrosative stress against impairment of renal organic anion transport in an study.在一项研究中，屈青提取物对肾脏有机阴离子转运损伤具有抗氧化、抗炎和抗亚硝化应激作用。
Nutr Res Pract. 2024 Oct;18(5):633-646. doi: 10.4162/nrp.2024.18.5.633. Epub 2024 Jul 19.
2
Pyrogallol from Inhibits Proliferation and Promotes Apoptosis in Castration-Resistant Prostate Cancer Cells via Modulating Akt/GSK-3/-catenin Signaling Pathway.没食子酚通过调节 Akt/GSK-3/-连环蛋白信号通路抑制去势抵抗性前列腺癌细胞的增殖并促进其凋亡。
Int J Mol Sci. 2023 Mar 29;24(7):6452. doi: 10.3390/ijms24076452.
3

本文引用的文献

1
Clinical implications of pathologic diagnosis and classification for diabetic nephropathy.糖尿病肾病病理诊断与分类的临床意义。
Diabetes Res Clin Pract. 2012 Sep;97(3):418-24. doi: 10.1016/j.diabres.2012.03.016. Epub 2012 Apr 21.
2
Lamin B1 loss is a senescence-associated biomarker.核层蛋白 B1 的缺失是衰老相关的生物标志物。
Mol Biol Cell. 2012 Jun;23(11):2066-75. doi: 10.1091/mbc.E11-10-0884. Epub 2012 Apr 11.
3
Onion peel extracts ameliorate hyperglycemia and insulin resistance in high fat diet/streptozotocin-induced diabetic rats.
Parboiled Germinated Brown Rice Improves Cardiac Structure and Gene Expression in Hypertensive Rats.
半熟发芽糙米改善高血压大鼠的心脏结构和基因表达。
Foods. 2022 Dec 20;12(1):9. doi: 10.3390/foods12010009.
4
Naringin attenuates fructose-induced NAFLD progression in rats through reducing endogenous triglyceride synthesis and activating the Nrf2/HO-1 pathway.柚皮苷通过减少内源性甘油三酯合成和激活Nrf2/HO-1通路来减轻果糖诱导的大鼠非酒精性脂肪性肝病进展。
Front Pharmacol. 2022 Dec 15;13:1049818. doi: 10.3389/fphar.2022.1049818. eCollection 2022.
5
Antidiabetic and Renoprotective Effects of Pulp Aqueous Extract through Preserving Organic Cation Transport System Mediated Oxidative Stress Pathway in Experimental Type 2 Diabetic Rats.通过保护有机阳离子转运系统介导的氧化应激途径对实验性 2 型糖尿病大鼠的降血糖和肾脏保护作用的果皮水提物。
Molecules. 2021 Mar 28;26(7):1907. doi: 10.3390/molecules26071907.
6
Mechanisms of Herbal Nephroprotection in diabetes mellitus.中草药在糖尿病肾病中的保护机制。
J Diabetes Res. 2020 Jun 30;2020:5710513. doi: 10.1155/2020/5710513. eCollection 2020.
7
Effects of as a dietary supplement on growth, pectoralis muscle performance, and small intestine morphology of broiler chickens.作为膳食补充剂对肉鸡生长、胸肌性能和小肠形态的影响。
Vet World. 2019 Aug;12(8):1233-1239. doi: 10.14202/vetworld.2019.1233-1239. Epub 2019 Aug 11.
8
Nutraceutical profile and evidence of alleviation of oxidative stress by Spirogyra porticalis (Muell.) Cleve inhabiting the high altitude Trans-Himalayan Region.螺旋藻（Muell.）Cleve 聚居的高海拔跨喜马拉雅地区的营养保健品特性和缓解氧化应激的证据。
Sci Rep. 2019 Mar 11;9(1):4091. doi: 10.1038/s41598-018-35595-x.
9
Culture of sp. in a flat-panel airlift photobioreactor.在平板气升式光生物反应器中培养某菌种。
3 Biotech. 2018 Jan;8(1):6. doi: 10.1007/s13205-017-1026-9. Epub 2017 Dec 8.
10
inhibits the absorption and synthesis of cholesterol .抑制胆固醇的吸收与合成。
Integr Med Res. 2016 Dec;5(4):301-308. doi: 10.1016/j.imr.2016.08.004. Epub 2016 Aug 22.
洋葱皮提取物可改善高脂饮食/链脲佐菌素诱导的糖尿病大鼠的高血糖和胰岛素抵抗。
Nutr Metab (Lond). 2011 Mar 28;8(1):18. doi: 10.1186/1743-7075-8-18.
4
Green tea extract decreases oxidative stress and improves insulin sensitivity in an animal model of insulin resistance, the fructose-fed rat.绿茶提取物可降低胰岛素抵抗动物模型（果糖喂养大鼠）的氧化应激，改善胰岛素敏感性。
J Am Coll Nutr. 2009 Aug;28(4):355-61. doi: 10.1080/07315724.2009.10718097.
5
Pathologic classification of diabetic nephropathy.糖尿病肾病的病理分类。
J Am Soc Nephrol. 2010 Apr;21(4):556-63. doi: 10.1681/ASN.2010010010. Epub 2010 Feb 18.
6
Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology.有机阴离子转运体：发现、药理学、调控及在病理生理学中的作用。
Biopharm Drug Dispos. 2010 Jan;31(1):1-71. doi: 10.1002/bdd.693.
7
Angiotensin II inhibits activity of human organic anion transporter 3 through activation of protein kinase Calpha: accelerating endocytosis of the transporter.血管紧张素 II 通过激活蛋白激酶 Calpha 抑制人有机阴离子转运蛋白 3 的活性：加速转运蛋白的内吞作用。
Eur J Pharmacol. 2010 Feb 10;627(1-3):49-55. doi: 10.1016/j.ejphar.2009.10.048. Epub 2009 Oct 28.
8
Role of basolateral efflux transporter MRP4 in the intestinal absorption of the antiviral drug adefovir dipivoxil.基底外侧外排转运体MRP4在抗病毒药物阿德福韦酯肠道吸收中的作用。
Biochem Pharmacol. 2010 Feb 1;79(3):455-62. doi: 10.1016/j.bcp.2009.08.029. Epub 2009 Sep 6.
9
Renal and hepatic transporter expression in type 2 diabetic rats.2型糖尿病大鼠的肾脏和肝脏转运体表达
Drug Metab Lett. 2008 Jan;2(1):11-7. doi: 10.2174/187231208783478425.
10
Activation of protein kinase Czeta increases OAT1 (SLC22A6)- and OAT3 (SLC22A8)-mediated transport.蛋白激酶Cζ的激活增强了OAT1（溶质载体家族22成员6）和OAT3（溶质载体家族22成员8）介导的转运。
J Biol Chem. 2009 Jan 30;284(5):2672-2679. doi: 10.1074/jbc.M808078200. Epub 2008 Nov 21.