Department of Organic Chemistry, Prague Institute of Chemical Technology, Technicka 5, 166 28 Prague 6, Czech Republic.
Org Biomol Chem. 2013 Sep 7;11(33):5528-34. doi: 10.1039/c3ob41085d.
A direct mercuration reaction combined with a subsequent Pd-catalyzed arylation was used to introduce the aryl moiety into the meta position of the calix[4]arene skeleton. The application of organomercurial intermediates thus allows the straightforward formation of meta-aryl-substituted derivatives representing a unique substitution pattern in calixarene chemistry.
直接汞化反应与随后的钯催化芳基化反应相结合，将芳基部分引入杯[4]芳烃骨架的间位。有机汞中间体的应用使得间位芳基取代衍生物的直接形成成为可能，这在杯芳烃化学中代表了一种独特的取代模式。
