Universidad Carlos III de Madrid, Departamento de Bioingeniería e Ingeniería Aeroespacial, 28911 Leganés, Spain.
J Biomed Opt. 2013 Jul;18(7):076016. doi: 10.1117/1.JBO.18.7.076016.
Fluorescence diffuse optical tomography (fDOT) is a noninvasive imaging technique that makes it possible to quantify the spatial distribution of fluorescent tracers in small animals. fDOT image reconstruction is commonly performed by means of iterative methods such as the algebraic reconstruction technique (ART). The useful results yielded by more advanced l1-regularized techniques for signal recovery and image reconstruction, together with the recent publication of Split Bregman (SB) procedure, led us to propose a new approach to the fDOT inverse problem, namely, ART-SB. This method alternates a cost-efficient reconstruction step (ART iteration) with a denoising filtering step based on minimization of total variation of the image using the SB method, which can be solved efficiently and quickly. We applied this method to simulated and experimental fDOT data and found that ART-SB provides substantial benefits over conventional ART.
荧光漫射光学断层成像术（fDOT）是一种非侵入性成像技术，可实现小动物体内荧光示踪剂的空间分布定量。fDOT 图像重建通常通过迭代方法（如代数重建技术（ART））来实现。更先进的 l1-正则化技术在信号恢复和图像重建方面的有用结果，以及最近发布的分裂布格曼（SB）算法，促使我们提出了一种新的 fDOT 反问题方法，即 ART-SB。该方法交替进行高效的重建步骤（ART 迭代）和基于 SB 方法最小化图像全变差的去噪滤波步骤，该方法可以高效快速地求解。我们将该方法应用于模拟和实验 fDOT 数据，发现 ART-SB 相对于传统的 ART 提供了实质性的益处。
