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本文引用的文献

1
Pharmacological closure of ductus arteriosus in preterm infants using indomethacin.使用吲哚美辛对早产儿动脉导管进行药物性闭合。
Arch Dis Child. 1980 Apr;55(4):271-6. doi: 10.1136/adc.55.4.271.
2
Effectiveness and pharmacokinetics of indomethacin in premature newborns with patent ductus arteriosus.吲哚美辛治疗早产儿动脉导管未闭的有效性及药代动力学
Eur J Clin Pharmacol. 1980 Jul;18(1):83-8. doi: 10.1007/BF00561483.
3
Indomethacin and bilirubin-albumin binding.吲哚美辛与胆红素 - 白蛋白结合
Dev Pharmacol Ther. 1982;4(3-4):124-31. doi: 10.1159/000457401.
4
Indomethacin and the preterm infant with a patent ductus arteriosus: relationship between plasma concentration and ductus closure.
Dev Pharmacol Ther. 1982;4(1-2):37-46. doi: 10.1159/000457389.
5
Intravenous indomethacin therapy in premature infants with persistent ductus arteriosus--a double-blind controlled study.静脉注射吲哚美辛治疗早产儿动脉导管未闭——一项双盲对照研究。
J Pediatr. 1981 Jan;98(1):137-45. doi: 10.1016/s0022-3476(81)80560-4.
6
Indomethacin treatment in patent ductus arteriosus. A double-blind study utilizing indomethacin plasma levels.吲哚美辛治疗动脉导管未闭。一项利用吲哚美辛血浆水平的双盲研究。
Dev Pharmacol Ther. 1980;1(2-3):125-36.
7
Determination of unbound bilirubin in the serum of newborns.新生儿血清中游离胆红素的测定。
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8
Protein binding of indomethacin: binding of indomethacin to human plasma albumin and its displacement from binding by ibuprofen, phenylbutazone and salicylate, in vitro.吲哚美辛的蛋白结合：吲哚美辛与人血浆白蛋白的结合及其在体外被布洛芬、保泰松和水杨酸盐从结合中置换出来的情况。
Pharmacology. 1974;12(1):12-9. doi: 10.1159/000136516.
9
Response of the patent ductus arteriosus to indomethacin treatment.动脉导管未闭对吲哚美辛治疗的反应。
Am J Dis Child. 1987 Mar;141(3):294-7. doi: 10.1001/archpedi.1987.04460030072028.
10
Prolonged indomethacin treatment in preterm infants with symptomatic patent ductus arteriosus: efficacy, drug level monitoring, and patient selection.对有症状的动脉导管未闭早产儿进行吲哚美辛延长治疗：疗效、药物水平监测及患者选择
Eur J Pediatr. 1987 Mar;146(2):140-4. doi: 10.1007/BF02343219.

吲哚美辛对胆红素与白蛋白结合的影响。

Effect of indomethacin on binding of bilirubin to albumin.

作者信息

Lam B C, Wong H N, Yeung C Y

机构信息

Department of Paediatrics, Queen Mary Hospital, University of Hong Kong.

出版信息

Arch Dis Child. 1990 Jul;65(7 Spec No):690-1. doi: 10.1136/adc.65.7_spec_no.690.

DOI:10.1136/adc.65.7_spec_no.690
PMID:2386402
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1590185/
Abstract

The effect of indomethacin on the binding of bilirubin to protein was studied in vitro by the horseradish peroxidase oxidation method. Plasma indomethacin concentrations ranging from 1500 micrograms/l to 4500 micrograms/l, which were much higher than the therapeutic concentrations achieved in vivo, were used for the studies. The bilirubin-protein titration curves obtained indicate that indomethacin, although protein bound, does not affect the binding of bilirubin to protein. Our study confirms that it is safe to use conventional doses of indomethacin in jaundiced preterm infants.

摘要

采用辣根过氧化物酶氧化法在体外研究了吲哚美辛对胆红素与蛋白质结合的影响。研究中使用的血浆吲哚美辛浓度范围为1500微克/升至4500微克/升，该浓度远高于体内达到的治疗浓度。所得的胆红素-蛋白质滴定曲线表明，吲哚美辛虽然与蛋白质结合，但并不影响胆红素与蛋白质的结合。我们的研究证实，在黄疸早产儿中使用常规剂量的吲哚美辛是安全的。