吲哚美辛对胆红素与白蛋白结合的影响。
Effect of indomethacin on binding of bilirubin to albumin.
作者信息
Lam B C, Wong H N, Yeung C Y
机构信息
Department of Paediatrics, Queen Mary Hospital, University of Hong Kong.
出版信息
Arch Dis Child. 1990 Jul;65(7 Spec No):690-1. doi: 10.1136/adc.65.7_spec_no.690.
The effect of indomethacin on the binding of bilirubin to protein was studied in vitro by the horseradish peroxidase oxidation method. Plasma indomethacin concentrations ranging from 1500 micrograms/l to 4500 micrograms/l, which were much higher than the therapeutic concentrations achieved in vivo, were used for the studies. The bilirubin-protein titration curves obtained indicate that indomethacin, although protein bound, does not affect the binding of bilirubin to protein. Our study confirms that it is safe to use conventional doses of indomethacin in jaundiced preterm infants.
采用辣根过氧化物酶氧化法在体外研究了吲哚美辛对胆红素与蛋白质结合的影响。研究中使用的血浆吲哚美辛浓度范围为1500微克/升至4500微克/升，该浓度远高于体内达到的治疗浓度。所得的胆红素-蛋白质滴定曲线表明，吲哚美辛虽然与蛋白质结合，但并不影响胆红素与蛋白质的结合。我们的研究证实，在黄疸早产儿中使用常规剂量的吲哚美辛是安全的。
Zotero 插件