Wang Jingwen, Deng Lei, Lu You
West China Medicine School, Sichuan University, Chengdu 610041, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2013 Jun;30(3):675-8.
Cancer stem cells (CSCs) and angiogenesis play important roles in generation and development of malignant tumours. The number of researches concerned both of them is increasing rapidly and many impressive conclusions have been achieved based on recent studies. It is indicated that the CSCs have complicated interaction with the adjacent vascular microenvironment and they act on the disease progression together. CSCs may enhance angiogenesis while the vascular microenvironment has effects on maintenance and even induction of stemness, and new illustrations of mechanisms are constantly obtained. In this review, we summarize the current research status of mutual actions between CSCs and the vascular microenvironment, and also overview the latest progresses about relevant targeted therapies, to provide advisable information for future preclinical and clinical explorations.
癌症干细胞（CSCs）与血管生成在恶性肿瘤的发生和发展中发挥着重要作用。针对这两者的研究数量正在迅速增加，并且基于近期研究已经取得了许多令人瞩目的结论。研究表明，癌症干细胞与相邻的血管微环境存在复杂的相互作用，它们共同影响疾病进展。癌症干细胞可能会促进血管生成，而血管微环境则对干细胞特性的维持甚至诱导具有影响，并且不断有新的机制阐释被发现。在本综述中，我们总结了癌症干细胞与血管微环境之间相互作用的当前研究现状，同时概述了相关靶向治疗的最新进展，为未来的临床前和临床探索提供有益信息。
