Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China; Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing 400038, China.
Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China; Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing 400038, China.
Cancer Lett. 2016 Oct 1;380(2):561-567. doi: 10.1016/j.canlet.2015.05.010. Epub 2015 May 12.
Cancer stem cells (CSCs) locate in and interact with particular vascular niches to maintain their stemness. CSCs induce, remodel and participate in the formation of microenvironmental niches to facilitate survival, stemness and escape from radio-/chemo-/bio-therapies. Neovasculature in tumor is often basement membrane-deficient and enriched with CSC-derived endothelial cells (ECs) and other mural cells, which may promote tumor invasion and metastasis. The aim of this review is to summarize recent findings about the crosstalk between CSCs and their vascular niches and discuss the potential therapeutic significance.
癌症干细胞（CSCs）位于特定的血管龛位并与之相互作用，以维持其干细胞特性。CSCs 诱导、重塑并参与微环境龛位的形成，以促进其存活、干细胞特性和逃避放化疗/生物治疗。肿瘤中的新生血管通常缺乏基底膜，并富含 CSC 衍生的内皮细胞（EC）和其他壁细胞，这可能促进肿瘤的侵袭和转移。本综述的目的是总结 CSCs 与其血管龛位之间相互作用的最新发现，并讨论其潜在的治疗意义。
