Kaur S, Bajwa P
School of Biotechnology, Gautam Buddha University, Greater Noida, 201308, Uttar Pradesh, India,
Clin Transl Oncol. 2014 Feb;16(2):115-21. doi: 10.1007/s12094-013-1103-4. Epub 2013 Aug 27.
Accumulating evidence suggests the involvement of stem cells in tumor angiogenesis. Two major types of stem cells frequently discussed in this regard are bone marrow-derived endothelial progenitor cells (EPCs) and tumor-derived cancer stem cells (CSCs). The present review discusses the possibility of a close association between these two cell types that drives the tumor towards metastasis. An exploration of this plausible relationship between EPCs and CSCs is imperative to completely unveil the mechanisms of tumor angiogenesis and develop CSC- and/or EPC-targeted anti-tumor therapies.
越来越多的证据表明干细胞参与肿瘤血管生成。在这方面经常讨论的两种主要干细胞类型是骨髓来源的内皮祖细胞（EPC）和肿瘤来源的癌症干细胞（CSC）。本综述讨论了这两种细胞类型之间密切关联的可能性，这种关联会促使肿瘤发生转移。探究EPC和CSC之间这种可能的关系对于全面揭示肿瘤血管生成机制以及开发针对CSC和/或EPC的抗肿瘤治疗方法至关重要。
