多发性硬化症女性的妊娠及围产期结局：匈牙利南部的一项回顾性病例对照研究
Pregnancy and perinatal outcomes among women with multiple sclerosis: a retrospective case-controlled study in South Hungary.
作者信息
Vanya Melinda, Nyari Tibor, Bencsik Krisztina, Bartfai György
机构信息
Department of Obstetrics and Gynaecology, Faculty of General Medicine .
出版信息
J Matern Fetal Neonatal Med. 2014 Apr;27(6):577-81. doi: 10.3109/14767058.2013.825596. Epub 2013 Aug 19.
OBJECTIVE
The aim of this study was to investigate the connections between multiple sclerosis (MS) and fertility, pregnancy.
METHODS
The case histories and pregnancy complications in a sample of 65 treatment-naive pregnant women with MS in the period 1998-2012 were compared with an age-matched case-controlled analysis. Comparisons were made between primigravidas and multigravidas subjects.
RESULTS
Our results revealed a higher rate of miscarriage (18.46%) in the first trimester in women with MS, and intrauterine death (7.69%) in the third trimester, as compared with women without MS (p < 0.001 and p = 0.035).
CONCLUSIONS
These findings suggest that, the risk of miscarriages and intrauterine death may be disease-related not drug-related feature. Further studies are needed to determine to possible associated factors of miscarriages.
目的
本研究旨在调查多发性硬化症（MS）与生育能力、妊娠之间的联系。
方法
对1998年至2012年期间65例未经治疗的患有MS的初孕妇女的病史和妊娠并发症进行了比较，并进行了年龄匹配的病例对照分析。对初产妇和经产妇进行了比较。
结果
我们的结果显示，与无MS的女性相比，患有MS的女性在孕早期流产率较高（18.46%），在孕晚期宫内死亡率较高（7.69%）（p<0.001和p=0.035）。
结论
这些发现表明，流产和宫内死亡的风险可能是与疾病相关而非与药物相关的特征。需要进一步研究以确定流产可能的相关因素。
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