Pouillot Anne, Polla Ada, Polla Barbara S
Alchimie Forever Sàrl, 4 place du Molard, 1204 Geneva, Switzerland.
Curr Aging Sci. 2013 Dec;6(3):225-31. doi: 10.2174/18746098112059990037.
Similar to oxygen, iron is essential for aerobic life and energy production. Akin to oxygen, iron can be toxic and accelerate the aging process. Indeed, via the Fenton and Haber Weiss reactions, iron potentiates the generation of highly reactive oxygen free radicals such as hydroxyl radical, thus stimulating oxidative damage. The possibility that women's longer life span relates to a lower iron status due to iron loss during reproductive life has been considered as a valid hypothesis, while hemochromatosis has been proposed as a model of iron overload to examine the effects of iron on the aging process. Iron plays an aggravating role in many diseases in which iron deprivation has been shown to be beneficial including ischaemia-reperfusion injury, neurological disorders and muscle diseases such as Duchenne's muscular dystrophy. In the skin, excess iron combined with UV radiation exerts pro-oxidant effects while scavenging of free iron prevents or inhibits the toxic effects of UV radiation on both nude mice and human skin. In this review, we propose that iron chelators and/or iron deprivation might play a significant role in the prevention of aging- associated diseases and conditions, in particular in the skin, and increase quality of life. Controlled iron deprivation might be achieved by regular blood donation in which case the quality of life of both the donor and the recipient is improved. Increasing the frequency of blood donation may thus significantly contribute to both individual and social wellbeing. Furthermore, we propose the skin as an accessible model for the study of aging and the effects of iron / iron deprivation on the aging mechanisms. Finally, we suggest that the development of topical iron chelators might represent a novel and simple approach to prevent skin aging, when such prevention has proven an important factor in increasing an aging populations' quality of life.
与氧气一样，铁对于有氧生命和能量产生至关重要。与氧气类似，铁也可能具有毒性并加速衰老过程。事实上，通过芬顿反应和哈伯-韦斯反应，铁会增强高活性氧自由基（如羟基自由基）的生成，从而引发氧化损伤。女性寿命较长可能与生殖期铁流失导致铁状态较低有关，这一可能性已被视为一个合理的假设，而血色素沉着症则被提议作为铁过载模型，用于研究铁对衰老过程的影响。铁在许多疾病中起加重作用，而铁缺乏已被证明对这些疾病有益，包括缺血再灌注损伤、神经疾病以及杜氏肌营养不良等肌肉疾病。在皮肤中，过量的铁与紫外线辐射结合会产生促氧化作用，而清除游离铁可预防或抑制紫外线辐射对裸鼠和人类皮肤的毒性作用。在本综述中，我们提出铁螯合剂和/或铁缺乏可能在预防与衰老相关的疾病和状况方面发挥重要作用，尤其是在皮肤方面，并可提高生活质量。通过定期献血可以实现可控的铁缺乏，在这种情况下，献血者和受血者的生活质量都会得到改善。因此，增加献血频率可能会对个人和社会福祉做出重大贡献。此外，我们提出皮肤可作为研究衰老以及铁/铁缺乏对衰老机制影响的一个易于研究的模型。最后，我们认为，当预防已被证明是提高老年人群生活质量的一个重要因素时，开发局部铁螯合剂可能是预防皮肤衰老的一种新颖且简单的方法。
