Karisma Vega Widya, Wu Wei, Lei Mingxing, Liu Huawen, Nisar Muhammad Farrukh, Lloyd Matthew D, Pourzand Charareh, Zhong Julia Li
Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing, China.
Three Gorges Central Hospital, Chongqing, China.
Front Cell Dev Biol. 2021 Feb 11;9:598717. doi: 10.3389/fcell.2021.598717. eCollection 2021.
Light has attracted special attention as a stimulus for triggered drug delivery systems (DDS) due to its intrinsic features of being spatially and temporally tunable. Ultraviolet A (UVA) radiation has recently been used as a source of external light stimuli to control the release of drugs using a "switch on- switch off" procedure. This review discusses the promising potential of UVA radiation as the light source of choice for photo-controlled drug release from a range of photo-responsive and photolabile nanostructures photo-isomerization, photo-cleavage, photo-crosslinking, and photo-induced rearrangement. In addition to its clinical use, we will also provide here an overview of the recent UVA-responsive drug release approaches that are developed for phototherapy and skin photoprotection.
由于光在空间和时间上具有可调节的固有特性，它作为触发药物递送系统（DDS）的刺激因素已引起特别关注。最近，紫外线A（UVA）辐射已被用作外部光刺激源，通过“开启-关闭”程序来控制药物释放。本综述讨论了UVA辐射作为从一系列光响应性和光不稳定纳米结构（光异构化、光裂解、光交联和光诱导重排）中进行光控药物释放的首选光源的潜在前景。除了其临床应用外，我们还将在此概述最近为光疗和皮肤光保护而开发的UVA响应性药物释放方法。
