Ormoz Psychiatric Hospital, Department for Clinical Pharmacy, Slovenia, Ptujska Cesta 33, Ormoz, Slovenia.
Gen Hosp Psychiatry. 2013 Nov-Dec;35(6):682.e3-4. doi: 10.1016/j.genhosppsych.2013.06.002. Epub 2013 Jul 15.
Solifenacin-induced cognitive adverse effects have not been reported frequently, but solifenacin-induced delirium and hallucinations with successful switching to darifenacin, without additional drug, have not been reported in the literature. In this case report, we present an 80-year-old Caucasian male with insomnia and anxiety symptoms and overactive bladder who developed delirium and hallucinations when treated with solifenacin and trazodone. After solifenacin discontinuation and switching to darifenacin, symptoms significantly improved immediately. Such a case has not yet been described in literature; however, an adverse effect associated with solifenacin can occur, as this report clearly demonstrates.
索利那新引起的认知不良反应并不常见，但文献中尚未报道过索利那新引起的谵妄和幻觉，而改用达非那新后无需加用其他药物即可缓解。在本病例报告中，我们介绍了一位 80 岁的白人男性，他因失眠和焦虑症状以及膀胱过度活动症而接受索利那新和曲唑酮治疗，随后出现了谵妄和幻觉。停止使用索利那新并改用达非那新后，症状立即显著改善。这种情况在文献中尚未描述；然而，正如本报告清楚表明的那样，索利那新可能会出现不良反应。
