[血清维生素D水平与幼儿社区获得性肺炎严重程度的相关性]
[Correlation between serum vitamin D level and severity of community acquired pneumonia in young children].
作者信息
Ren Jing, Sun Bin, Miao Po, Feng Xing
机构信息
Children's Hospital of Soochow University, Suzhou, Jiangsu 215003, China.
出版信息
Zhongguo Dang Dai Er Ke Za Zhi. 2013 Jul;15(7):519-21.
OBJECTIVE
To study the correlation between serum vitamin D level and severity of community acquired pneumonia (CAP) in young children, and explore related risk factors for CAP.
METHODS
One hundred and three children with CAP between October 2011 and April 2012 were enrolled in the study, including 15 cases of severe CAP and 88 cases of mild CAP. Ninety healthy children were used as the control group. 25-(OH)D(3) concentrations were measured by enzyme linked immunoassay.
RESULTS
The mean vitamin D concentration in the severe CAP group was significantly lower than in the mild CAP and control groups (P < 0.01), and there was no significant difference between the mild CAP and control groups (P = 0.674). Premature birth and vitamin D < 50 nmol/L were risk factors for severe CAP in the multivariate analysis.
CONCLUSIONS
Vitamin D deficiency might be associated with the severity of CAP in young children.
目的
研究幼儿血清维生素D水平与社区获得性肺炎（CAP）严重程度之间的相关性，并探讨CAP的相关危险因素。
方法
选取2011年10月至2012年4月期间103例CAP患儿，其中重度CAP 15例，轻度CAP 88例。选取90例健康儿童作为对照组。采用酶联免疫法测定25-（OH）D3浓度。
结果
重度CAP组维生素D平均浓度显著低于轻度CAP组和对照组（P<0.01），轻度CAP组和对照组之间差异无统计学意义（P=0.674）。多因素分析显示早产和维生素D<50 nmol/L是重度CAP的危险因素。
结论
维生素D缺乏可能与幼儿CAP的严重程度有关。
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