Brance María L, Miljevic Julio N, Tizziani Raquel, Taberna María E, Grossi Georgina P, Toni Pablo, Valentini Elina, Trepat Andrea, Zaccardi Julia, Moro Juan, Finuci Curi Baltasar, Tamagnone Norberto, Ramirez Mariano, Severini Javier, Chiarotti Pablo, Consiglio Francisco, Piñeski Raúl, Ghelfi Albertina, Kilstein Jorge, Street Eduardo, Moretti Dino, Oliveto Viviana, Mariño Marcelo, Manera Jorge, Brun Lucas R
Bone Biology Laboratory, School of Medicine, Rosario National University, Rosario, Argentina.
National Council of Scientific and Technical Research (CONICET), Rosario, Argentina.
Clin Respir J. 2018 Jul;12(7):2220-2227. doi: 10.1111/crj.12792. Epub 2018 Apr 16.
Community-acquired pneumonia (CAP) is the infectious disease with the highest number of deaths worldwide. Several studies have shown an association between vitamin D deficiency and increases susceptibility to respiratory tract infections.
The aim of this study was to evaluate the serum 25-hydroxyvitamin D (25OHD) levels in hospitalized adults in general room with CAP.
An observational study was carried out in 207 hospitalized adults of both sex with CAP (>18 years) from Rosario city, Argentina (32° 52' 18″S) between July 2015 and June 2016.
In total, 167 patients were included in the data analysis [59% women (57.4 ± 19.6 years), body mass index 27.2 ± 7.8 kg/m ]. In brief, 63% showed unilobar infiltrate and 37% were multilobar. The CURB-65 index was 66.5% low risk, 16.0% intermediate risk and 17.5% high risk. According to Charlson comorbidity index (CCI) 53.5% had not comorbidity (CCI = 0) and 46.5% showed CCI ≥ 1. The 25OHD level was: 11.92 ± 7.6 ng/mL (51.5%: <10 ng/mL, 33.5%: 10-20 ng/mL, 13.2%: 20-30 ng/mL and 1.8%: >30 ng/mL). Higher 25OHD were found in male (female: 10.8 ± 6.7 ng/mL, male: 13.5 ± 8.5 ng/mL, P = .02) and 25OHD correlated with age (r = -.17; P = .02). 25-Hydroxyvitamin D was also correlated with CURB65 index (r = -.13; P = .049), CCI (r = -.20, P = .007) and with the 10 years of life expectative (%) (r = .19; P = .008). In addition, higher 25OHD were found with lower CCI (CCI 0 = 13.0 ± 8.2 ng/mL, CCI ≥ 1= 10.5 ± 6.7 ng/mL; P = .0093).
Hospitalized adults with CAP have lower 25OHD levels and would be associated with the severity of CAP.
社区获得性肺炎（CAP）是全球死亡人数最多的传染病。多项研究表明维生素D缺乏与呼吸道感染易感性增加之间存在关联。
本研究旨在评估入住普通病房的成年CAP患者的血清25-羟维生素D（25OHD）水平。
2015年7月至2016年6月期间，对来自阿根廷罗萨里奥市（南纬32°52′18″）的207例年龄大于18岁的住院成年CAP患者（男女均有）进行了一项观察性研究。
共有167例患者纳入数据分析[女性占59%（57.4±19.6岁），体重指数27.2±7.8kg/m²]。简而言之，63%表现为单叶浸润，37%为多叶浸润。CURB-65指数显示低风险为66.5%，中度风险为16.0%，高风险为17.5%。根据Charlson合并症指数（CCI），53.5%无合并症（CCI=0），46.5%的CCI≥1。25OHD水平为：11.92±7.6ng/mL（51.5%：<10ng/mL，33.5%：10 - 20ng/mL，13.2%：20 - 30ng/mL，1.8%：>30ng/mL）。男性的25OHD水平更高（女性：10.8±6.7ng/mL，男性：13.5±8.5ng/mL，P=0.02），且25OHD与年龄相关（r=-0.17；P=0.02）。25-羟维生素D还与CURB65指数（r=-0.13；P=0.049）、CCI（r=-0.20，P=0.007）以及预期寿命10年（%）相关（r=0.19；P=0.008）。此外，CCI较低时25OHD水平较高（CCI 0=13.0±8.2ng/mL，CCI≥1=10.5±6.7ng/mL；P=0.0093）。
住院的成年CAP患者25OHD水平较低，且可能与CAP的严重程度相关。
