Nurulain Syed Muhammad
Department of Pharmacology and Therapeutics, FMHS, United Arab Emirates University, UAE.
J Pak Med Assoc. 2012 Jul;62(7):712-7.
Organophosphorus compounds (OPCs) have a wide variety of applications and are a serious threat for self-poisoning, unintentional misuse, terrorist attack, occupational hazard and warfare attack. The present standard treatment has been reported to be unsatisfactory. Many novel approaches are being used and tested for acute organophosphorus (OP) poison treatment. The bioscavenger concept captured high attention among the scientific community during the last few decades. Other approaches like alkalinisation of blood plasma/serum and use of weak inhibitors against strong inhibitors, though it showed promising results, did not get such wide attention. The introduction of a novel broad-spectrum oxime has also been in focus. In this mini-review, an update of the overview of four different approaches has been discussed. The standard therapy that is atropine+oxime+benzodiazepine along with supportive measures will continue to be the best option with only the replacement of a single oxime to improve its broad-spectrum efficacy.
有机磷化合物（OPCs）有广泛的应用，并且对自我中毒、无意误用、恐怖袭击、职业危害和战争攻击构成严重威胁。据报道，目前的标准治疗并不令人满意。许多新方法正在被用于急性有机磷（OP）中毒治疗并进行测试。在过去几十年里，生物清除剂概念在科学界引起了高度关注。其他方法，如血浆/血清碱化以及使用针对强抑制剂的弱抑制剂，尽管显示出了有前景的结果，但并未得到如此广泛的关注。新型广谱肟的引入也一直是焦点。在这篇小型综述中，讨论了四种不同方法概述的更新情况。标准疗法即阿托品+肟+苯二氮䓬并辅以支持措施，仍将是最佳选择，只需更换单一肟以提高其广谱疗效。
