单一培养的乳酸杆菌和双歧杆菌对正常及阴道葡萄球菌感染情况下阴道微生物群的影响。

The effect of Lacto- and Bifidobacteria in monoculture on the vaginal microflora in norm and in cases of intravaginal staphylococcosis.

作者信息

Babenko L R, Lazarenko L M, Shynkarenko L M, Mokrozub V V, Pidgorskyi V S, Spivak M Ja

机构信息

Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, 154, Zabolotny St., Kyiv D03680, Ukraine.

出版信息

Mikrobiol Z. 2013 May-Jun;75(3):46-55.

PMID:23866586

Abstract

The influence of probiotic strains of Lactobacillus casei IMV B-7280, Lactobacillus acidophilus IMV B-7279, Bifidobacterium animalis VKL, Lactobacillus delbrueckii subsp. bulgaricus IMV B-7281 and Bifidobacterium animalis VKB, each strain separately, to the range of the urogenital tract microflora in physiological norm and in cases of experimental intravaginal staphylococcosis of mice induced by Staphylococcus aureus 8325-4. It was found that all these strains had different efficiency in Staphylococcus aureus 8325-4 growth suppression in the vagina of infected mice and affect the spectrum of microorganisms. Lactobacillus casei IMV B-7280 strain had effective antistaphylococcal effect and reduced the number of coliform bacteria and fungi in the vagina in cases of intravaginal staphylococcosis of mice. Lactobacillus casei IMV B-7280 strain is promising to create probiotic drugs effective in treating intravaginal staphylococcosis.

摘要

干酪乳杆菌IMV B - 7280、嗜酸乳杆菌IMV B - 7279、动物双歧杆菌VKL、德氏乳杆菌保加利亚亚种IMV B - 7281和动物双歧杆菌VKB这些益生菌菌株，分别对处于生理正常状态以及由金黄色葡萄球菌8325 - 4诱导的小鼠实验性阴道葡萄球菌感染情况下的泌尿生殖道微生物群范围的影响。结果发现，所有这些菌株在抑制感染小鼠阴道内金黄色葡萄球菌8325 - 4生长方面具有不同的效率，并影响微生物谱。干酪乳杆菌IMV B - 7280菌株具有有效的抗葡萄球菌作用，在小鼠阴道葡萄球菌感染情况下可减少阴道内大肠菌群和真菌的数量。干酪乳杆菌IMV B - 7280菌株有望用于研发有效治疗阴道葡萄球菌感染的益生菌药物。