Bellussi Luisa, Cambi Jacopo, Passali Desiderio
ENT Department, University of Siena, Siena, Italy.
Multidiscip Respir Med. 2013 Jul 18;8(1):46. doi: 10.1186/2049-6958-8-46.
Secretory IgA (SIgA) plays an important role in defending the mucous membranes of the upper respiratory airways from common infection. Studying and comparing the values and the daily variation of SIgA in nasal secretion could explain the largest number of upper respiratory infection, especially in children.Moreover, the ELISA dosage of SIgA in nasal secretion, sampled by cotton swabs positioned between septum and middle turbinate for 20 minutes every 4 hours 5 times in a day, can be easily performed and shows significant differences between the healthy child and the healthy adult.Nasal secretion SIgA mean value is lower in the healthy child than in the healthy adult. Circadian variation for healthy child showed the highest value at 7.00 a.m., while in adult the highest value was at 4.00 a.m.These knowledge on SIgA may help to explain the highest number of upper airway infection during childhood and clarify the physiological cycle of production. Thus, in performing a SIgA dosage the time of sample must be considered and preferably it should be made at a standardized time of the day.
分泌型免疫球蛋白A（SIgA）在保护上呼吸道黏膜免受常见感染方面发挥着重要作用。研究和比较鼻腔分泌物中SIgA的值及其每日变化情况，有助于解释大多数上呼吸道感染病例，尤其是儿童的感染情况。此外，通过在鼻中隔和中鼻甲之间放置棉拭子，每4小时采样一次，每天采样5次，每次20分钟，来检测鼻腔分泌物中SIgA的酶联免疫吸附测定法易于操作，且显示出健康儿童与健康成人之间存在显著差异。健康儿童鼻腔分泌物中SIgA的平均值低于健康成人。健康儿童的昼夜变化显示上午7点时SIgA值最高，而成年人则在凌晨4点时最高。这些关于SIgA的知识可能有助于解释儿童期上呼吸道感染高发的原因，并阐明其产生的生理周期。因此，在进行SIgA检测时，必须考虑采样时间，最好在一天中的标准化时间进行采样。
