Zheng Jichang, Shen Haibo, Tan Bi'e, Yin Yulong, Wang Jing
Hunan Provincial Key Laboratory for the Products Quality Regulation of Livestock and Poultry, College of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, Hunan, China.
Yuelushan Laboratory, Changsha, 410128, China.
Porcine Health Manag. 2025 Jul 4;11(1):37. doi: 10.1186/s40813-025-00437-6.
This study aims to investigate the effects of maternal supplementation with galactooligosaccharides (GOS) on intestinal digestion, absorption, and barrier function of offspring. Twenty four late-pregnant Ningxiang sows were randomly assigned into 3 treatments, including basic diet, basic diet with 0.5% GOS, basic diet with 100 mg/kg aureomycin, 20mg/kg ciprofloxacin and 10mg/kg vancomycin. The results showed that maternal dietary supplementation of GOS increased the body weight and average daily gain, reduced the diarrhea score of piglets, and increased the activities of digestive enzymes including maltase and α-amylase. Maternal GOS improved the intestinal barrier integrity and function of piglets, which exhibiting with increased ileal ratio of villus to crypt, and higher expressions of secretory immunoglobulin A, tight junction protein and mucin-2 in ileum. Maternal GOS treatment increased the contents of anti-inflammatory factors IL-4, IL-10 and TGF-β, but decreased the contents of pro-inflammatory factors IL-1β, IL-6 in the ileum and colon of piglets. In addition, piglets in maternal GOS treatment had increased abundance of probiotics in the colonic contents, as well as higher short-chain fatty acids concentrations in the colonic and cecal contents. Overall, this study provides data support for the nutritional regulation of maternal supplementation with 0.5% GOS to promote intestinal health of offspring.
本研究旨在探讨母体补充低聚半乳糖（GOS）对后代肠道消化、吸收及屏障功能的影响。将24头妊娠后期的宁乡母猪随机分为3组，分别给予基础日粮、添加0.5% GOS的基础日粮、添加100 mg/kg金霉素、20 mg/kg环丙沙星和10 mg/kg万古霉素的基础日粮。结果表明，母体日粮中添加GOS可增加仔猪体重和平均日增重，降低腹泻评分，并提高包括麦芽糖酶和α-淀粉酶在内的消化酶活性。母体补充GOS可改善仔猪肠道屏障完整性和功能，表现为回肠绒毛与隐窝比值增加，回肠中分泌型免疫球蛋白A、紧密连接蛋白和黏蛋白-2的表达升高。母体GOS处理增加了仔猪回肠和结肠中抗炎因子IL-4、IL-10和TGF-β的含量，但降低了促炎因子IL-1β、IL-6的含量。此外，母体GOS处理的仔猪结肠内容物中益生菌丰度增加，结肠和盲肠内容物中短链脂肪酸浓度升高。总体而言，本研究为母体补充0.5% GOS促进后代肠道健康的营养调控提供了数据支持。
