Myers R E
Biol Neonate. 1975;26(1-2):21-43. doi: 10.1159/000240714.
Term monkey fetus 1620 sustained 50 min of rapidly developing severe asphyxia which began immediately after its in utero version. The arterial blood pO2 decreased from a normal value of 34 to 11-12 mm Hg while the blood pH fell from 7.35 to 6.70. During this asphyxia, hemoglobin-oxygen saturations below 5% were recorded. The complete collapse of the umbilical circulation several minutes prior to the reoxygenation of the fetus added an episode of total asphyxia. With reoxygenation following delivery, fetal cardiovascular performance improved rapidly though over an hour was required for recovery from the severe acidosis. The animal prospered but was found moribund on the 13th postnatal day due to dehydration. Brain examination after euthanasia revealed severe paracentral cortical and basal ganglia damage. Damage also appeared symmetrically in nuclei in the lower brain stem and in thalamus. These three zones of injury are attributed to the partial, the partial combined with the total, and the total asphyxia, respectively. The present case makes clear that compression of the umbilical cord may cause damage of a variety of types depending on the severity and duration of the asphyxia induced. It also demonstrates the possibility of recovery from a systemic acidosis where the pH values have fallen to levels below 6.70 for up to an hour.
猴胎儿1620经历了50分钟迅速发展的严重窒息，窒息在其子宫内翻转后立即开始。动脉血氧分压从正常的34毫米汞柱降至11 - 12毫米汞柱，而血液pH值从7.35降至6.70。在这种窒息期间，记录到血红蛋白氧饱和度低于5%。在胎儿复氧前几分钟脐循环完全停止，增加了一段完全窒息期。分娩后复氧时，胎儿心血管功能迅速改善，但从严重酸中毒中恢复需要一个多小时。这只动物存活下来，但在出生后第13天因脱水而奄奄一息。安乐死后的脑部检查显示，中央旁皮质和基底神经节严重受损。损伤在下脑干和丘脑的核团中也对称出现。这三个损伤区域分别归因于部分窒息、部分合并完全窒息以及完全窒息。本病例表明，脐带受压可能根据所诱发窒息的严重程度和持续时间导致各种类型的损伤。它还证明了在pH值降至6.70以下长达一小时的全身性酸中毒情况下恢复的可能性。
