Department of Physical Medicine and Rehabilitation, Mayo Clinic College of Medicine , Rochester, Minnesota.
Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine , Rochester, Minnesota.
Physiology (Bethesda). 2019 May 1;34(3):216-229. doi: 10.1152/physiol.00054.2018.
Spastic cerebral palsy (CP), despite the name, is not consistently identifiable by specific brain lesions. CP animal models focus on risk factors for development of CP, yet few reproduce the diagnostic symptoms. Animal models of CP must advance beyond risk factors to etiologies, including both the brain and spinal cord.
痉挛性脑瘫(CP),尽管名字如此,但其大脑病变并不总是具有特异性。CP 动物模型主要针对 CP 发病的危险因素,但很少能复制出诊断症状。CP 的动物模型必须超越危险因素,进入病因学研究,包括大脑和脊髓。