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[基层医疗领域抗生素处方的适宜性:一项横断面研究]

[Appropriateness of antibiotic prescribing in a primary care area: a cross-sectional study].

作者信息

Fernández-Urrusuno Rocío, Flores-Dorado Macarena, Vilches-Arenas Angel, Serrano-Martino Carmen, Corral-Baena Susana, Montero-Balosa M Carmen

机构信息

Servicio de Farmacia, Distrito Aljarafe, Sevilla, España.

Servicio de Farmacia, Distrito Aljarafe, Sevilla, España.

出版信息

Enferm Infecc Microbiol Clin. 2014 May;32(5):285-92. doi: 10.1016/j.eimc.2013.05.004. Epub 2013 Jul 16.

Abstract

OBJECTIVE

To assess the profile of patients receiving antibiotics and the appropriateness of these prescriptions for the clinical conditions.

DESIGN

Cross-sectional study of prescription-indication.

SETTING

A primary health care area in Andalusia.

SUBJECTS

Patients assigned to primary care centres. Patients with antibiotic prescriptions during 2009 were selected by simple random sampling (confidence level: 95%, accuracy: 5%). Primary endpoint: appropriateness of antibiotics prescribing to recommendations included in local guidelines. Data were obtained through the billing computerised prescriptions system and medical histories.

RESULTS

Twenty-five per cent of the population area received antibiotics during 2009. The 1,266 patient samples showed the following characteristics: 57.9% were women, with a mean age of 41 (±1) years. There were 39.3% pensioners. The percentage of appropriate antibiotic prescriptions was 19.9%, with no difference due to gender. Statistically significant differences were related to age, being those over 65 years the group of patients with the highest percentage of inappropriateness. The main reasons for inappropriateness were: no recording of the infectious process (44.5%), a wrong treatment duration (15.5%), and the use of an inadequate antibiotic (11.5%).

CONCLUSION

There is a high level of inappropriateness in antibiotic prescribing in primary care. The high level of under-recording of diagnoses, mainly in elderly patients, followed by the use of wrong schedules, and the wrong type of antibiotics were the main reasons of inappropriateness.

摘要

目的

评估接受抗生素治疗的患者概况以及这些处方针对临床病症的合理性。

设计

处方指征的横断面研究。

背景

安达卢西亚的一个初级卫生保健区域。

研究对象

分配到初级保健中心的患者。通过简单随机抽样(置信水平:95%,准确度:5%)选取2009年有抗生素处方的患者。主要终点:根据当地指南中的建议开具抗生素的合理性。数据通过计费电脑化处方系统和病历获取。

结果

2009年该地区25%的人口接受了抗生素治疗。1266例患者样本呈现以下特征:57.9%为女性,平均年龄41(±1)岁。39.3%为退休人员。抗生素处方合理的比例为19.9%,不存在性别差异。与年龄相关存在统计学显著差异,65岁以上患者组的不合理比例最高。不合理的主要原因是:未记录感染过程(44.5%)、治疗时长错误(15.5%)以及使用了不恰当的抗生素(11.5%)。

结论

初级保健中抗生素处方的不合理程度较高。诊断记录不充分的情况严重,主要发生在老年患者中,其次是治疗方案错误以及使用了错误类型的抗生素,这些是不合理的主要原因。

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